4-year mortality in patients with non-small-cell lung cancer: development and validation of a prognostic index

Blanchon, F; Grivaux, M; Asselain, Bernard; Lebas, François‐Xavier; Orlando, J.-P.; Piquet, J.; Zureik, Mahmoud

doi:10.1016/s1470-2045(06)70868-3

Cited by 109 publications

(95 citation statements)

References 26 publications

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“…A total of 434 confirmed lung cancer patients who were diagnosed and treated over a period of 3 years were analyzed. As compared to Western population, median age of our patients was a decade younger (Blanchon et al, 2006;Cetin et al, 2011;Albain et al, 1991). Most of the previous studies Indian have reported the similar median age (Behera et al, 2004;Singh et al,2010;Prasad et al 2004;Khan et al,2006).…”

Section: Discussionsupporting

confidence: 59%

“…In the series from west as well as from India, it is reported that 50-70% cases of NSCLC and up to 2/3rd of SCLC usually present in advanced stage (Behera et al, 2004;Blanchon et al, 2006;Govindan et al 2006;Grivaux et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…On multivariate analysis we found that PS>2, poorly differentiated histology and serum albumin levels <3.5mg/dl were associated with inferior survival however for progression free survival only PS>2 was found to be significant adverse risk factor. In a larger study of 4669 patients, Blanchon et al (2006) have developed a prognostic score for NSCLC and demonstrated that age, stage, PS, histology and treatment modalities used had a significant impact on survival. In SWOG (South-West Oncology Group) experience of advanced NSCLC, PS, female sex, age, haemoglobin and serum LDH were found to be independent prognostic factors (Albain et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

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Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik¹,

Sharma²,

Mohanti³

et al. 2013

Asian Pacific Journal of Cancer Prevention

103

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Background: Lung cancer is one of the commonest and most lethal cancers throughout the world. The epidemiological and pathological profile varies among different ethnicities and geographical regions. At present adenocarcinoma is the commonest histological subtype of non-small cell lung cancer (NSCLC) in most of the Western and Asian countries. However, in India squamous cell carcinoma has been reported as the commonest histological type in most of the series. The aim of the study was to analyze the current clinico-pathological profile and survival of lung cancer at our centre. Materials and Methods: We analyzed 434 pathologically confirmed lung cancer cases registered at our centre over a period of three years. They were evaluated for their clinical and pathological profiles, treatment received and outcome. The available histology slides were reviewed by an independent reviewer. Results: Median age was 55 years with a male:female ratio of 4.6:1. Some 68% of patients were smokers. There were 85.3% NSCLC and 14.7% SCLC cases. Among NSCLCs, adenocarcinoma was the commonest histological subtype after the pathology review. Among NSCLC, 56.8% cases were of stage IV while among SCLC 71.8% cases had extensive stage disease. Some 29% of patients did not receive any anticancer treatment. The median overall and progression free survivals of the patients who received treatment were 12.8 and 7.8 months for NSCLC and 9.1 and 6.8 months for SCLC. Conclusions: This analysis suggests that adenocarcinoma may now be the commonest histological subtype also in India, provided a careful pathological review is done. Most of the patients present at advanced stage and outcome remains poor.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik¹,

Sharma²,

Mohanti³

et al. 2013

Asian Pacific Journal of Cancer Prevention

103

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“…The French College of General Hospital Respiratory Physicians (CPHG) has conducted two prospective multicentre epidemiological studies at a 10-year interval: KBP-2000-CPHG and KBP-2010-CPHG (5)(6)(7)(8)(9). These studies included all consecutive new cases of primary lung cancer histologically or cytologically proven in 2000 or 2010 and followed in the respiratory department of non-academic hospitals.…”

Section: Introductionmentioning

confidence: 99%

New insights into stage and prognosis in small cell lung cancer: an analysis of 968 cases

Dayen¹,

Debieuvre²,

Molinier³

et al. 2017

J. Thorac. Dis.

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Background: The French College of General Hospital Respiratory Physicians conducted two studies that consecutively included all patients followed in participating general hospitals for primary small cell (SCLC) or non-small cell (NSCLC) lung cancer diagnosed in 2000 and 2010. These studies allow descriptive statistics and outcome assessment for SCLC and NSCLC separately and comparison over a 10-year period.Methods: A standardised form was completed for each patient at inclusion. Then, vital status was collected.

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“…Various studies have assessed the influence of prognostic factors like age, stage, PS histology, treatment modality, hemoglobin level and serum lactate dehydrogenase level on treatment but till date none observed the effect of these factors in the elderly population (16). Further studies are required to explore and validate these factors in the elderly subgroup.…”

Section: Discussionmentioning

confidence: 99%

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

et al. 2016

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Objectives: To evaluate treatment compliance, toxicity and survival in geriatric patients (≥65 years) with locally advanced nonsmall cell lung cancer (LA-NSCLC).Methods: Departmental archive was collected for the details of demographics, treatment and outcome in elderly patients with LA-NSCLC (2008 -2013) (n = 96). Both progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier method. Acute and late morbidity were scored using common terminology criteria for adverse events version 4, radiation therapy and oncology group late morbidity scoring system. Results:Overall treatment completion rate was 65%. The rates of acute grade ≥ 3 hematologic and non-hematologic toxicities were 20% and 17% respectively. Overall rate of late toxicity was 12.5%. The median PFS and OS values were 7.4 months and 10.54 months, respectively. Patients with multiple comorbidities, poor socio-economic background and serum albumin level (< 3.5g/dL) were observed to have poor survival. Survival was lower for non-compliant patients. Conclusions:Curative multi-modality therapy in elderly patients with LA-NSCLC is a challenging task. They are susceptible to poor compliance, treatment-associated toxicities and poor survival.

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4-year mortality in patients with non-small-cell lung cancer: development and validation of a prognostic index

Cited by 109 publications

References 26 publications

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

New insights into stage and prognosis in small cell lung cancer: an analysis of 968 cases

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India

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