[41] Topically applied antioxidants in skin protection

Folic acid and creatine improve the firmness of human skin in vivo

“…Human primary dermal fibroblasts (HDF) were cultured by outgrowth from skin biopsies obtained from different female donors (43–69 years) as previously described 9 . All donors provided written, informed consent.…”

Free radical scavenging and skin penetration of troxerutin and vitamin derivatives

“…[7][8][9] Amongst such antioxidants, ascorbic acid and alpha-tocopheryl are widely used [10][11][12][13][14] and some authors have suggested that avonoids, which have antiin ammatory and antioxidant properties, would also be capable of reducing the damage caused by oxidative stress to the skin. 15,16 Moreover, there is some evidence showing synergism between ascorbic acid and alpha-tocopheryl for free radical scavenging by recycling each other, [17][18][19][20][21] and the addition of a avonoid (i.e.…”

Decreased fibroblast contractile activity and reduced fibronectin expression are involved in skin photoaging

“…Its function in cell-ECM and cell-matrix adhesion site interactions [6,7] links FN to cell contraction and matrix assembly. Human dermal fibroblasts used for these experiments were isolated by outgrowth from skin biopsies obtained from different female donors (45-72 years) as described previously [10]. In experimental settings significantly differing from ours, Chen et al [8] reported that exposure to selective UVA irradiation did not Fig.…”