432 Comparison of Efficiency and Side Effect of Adriamycin and Doxetaxel and Adriamycin, Cyclophosphamide and Paclitaxel in Patients with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy

Hong, Wen; Kim, K.; Jung, Yun Seo; Kim, Jihye; Kang, Sona; Chun, June Young; Chun, Mi Son; Yim, Hyunee; Kang, Di; Kim, T.

doi:10.1016/s0959-8049(12)70498-7

Cited by 4 publications

(4 citation statements)

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“…Surgery, radiotherapy and chemotherapy remain the mainstay of treatment for malignant tumors. Although gene therapy and monoclonal antibody therapy have good therapeutic efficacy, they adapt to limited patients due to the high cost ( Hong et al, 2012 ) . Among various chemotherapeutic drugs, Paclitaxel (PTX) is the first-line drug for the treatment of breast cancer, but it may cause bone marrow suppression and hepatorenal toxicity, which reduces human tolerance to PTX.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models

et al. 2021

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Background: Combination of the prodrug technique with an albumin nano drug-loaded system is a novel promising approach for cancer treatment. However, the long-lasting and far-reaching challenge for the treatment of cancers lies in how to construct the albumin nanometer drug delivery system with lead compounds and their derivatives. Methods: In this study, we reported the preparation of injectable albumin nanoparticles (NPs) with a high and quantitative drug loading system based on the Nab TM technology of paclitaxel palmitate (PTX-PA).Results: Our experimental study on drug tissue distribution in vivo demonstrated that the paclitaxel palmitate albumin nanoparticles (Nab-PTX-PA) remained in the tumor for a longer time post-injection. Compared with saline and paclitaxel albumin nanoparticles (Abraxane V R ), intravenous injection of Nab-PTX-PA not only reduced the toxicity of the drug in normal organs, and increased the body weight of the animals but maintained sustained release of paclitaxel (PTX) in the tumor, thereby displaying an excellent antitumor activity. Blood routine analysis showed that Nab-PTX-PA had fewer adverse effects or less toxicity to the normal organs, and it inhibited tumor cell proliferation more effectively as compared with commercial paclitaxel albumin nanoparticles. Conclusions: This carrier strategy for small molecule drugs is based on naturally evolved interactions between long-chain fatty acids (LCFAs) and Human Serum Albumin (HSA), demonstrated here for PTX. Nab-PTX-PA shows higher antitumor efficacy in vivo in breast cancer models. On the whole, this novel injectable Nab-PTX-PA has great potential as an effective drug delivery system in the treatment of breast cancer.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models

et al. 2021

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“…Although gene therapy and monoclonal antibody therapy have good therapeutic e cacy, they adapt to limited patients due to the high cost [1]. Among various chemotherapeutic drugs, PTX is the rst-line drug for the treatment of breast cancer, but it may cause bone marrow suppression and hepatorenal toxicity, which reduces human tolerance to PTX.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Paclitaxel Palmitate Albumin Nanoparticles With High Loading Efficacy: an in Vitro and in Vivo Anti-tumor Study in Mouse Models

Chen

Huang

Wang³

et al. 2020

Preprint

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Background: Combination of the prodrug technique with an albumin nanodrug-loaded system is a novel promising approach for cancer treatment. However, the long-lasting and far-reaching challenge for the treatment of cancers lies in how to construct the albumin nanometer drug delivery system with lead compounds and their derivatives. Results: In this study, we reported the preparation of injectable albumin nanoparticles (NPs) with a high and quantitative drug loading system based on the NabTM technology of paclitaxel palmitate (PTX-PA). Our experimental study on drug tissue distribution in vivo demonstrated that the paclitaxel palmitate albumin NPs (Nab-PTX-PA) remained in the tumor for a longer time post injection. Compared with saline and Abraxane® (nanoparticle albumin-bound (nab)-paclitaxel), intravenous injection of Nab-PTX-PA not only reduced the toxicity of the drug in normal organs and increased the body weight of the animals but maintained sustained release of paclitaxel (PTX) in the tumor, thereby displaying an excellent antitumor activity. Blood routine analysis showed that Nab-PTX-PA had fewer adverse effects or less toxicity to the normal organsand more importantly it inhibited tumor cell proliferation more effectively as compared with commercial Abraxane®.Conclusions: This carrier strategy for small molecule drugs is based on naturally evolved interactions between LCFAs(Long Chain Fatty Acids) and HSA(human serum albumin), demonstrated here for PTX. Nab-PTX-PA shows higher maximum tolerated doses and increased efficacy in vivo in breast cancer models, as compared to Abraxane for FDA-approved clinical formulations. This novel injectable Nab-PTX-PA platform has great potential as an effective drug delivery system in the treatment of breast cancer.

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“…[5][6][7][8][9][10][11] These efforts are expected to overcome the side effects by prolonging the systematic circulation and to target drugs to tumor sites via passive and active targeting. [12][13][14][15][16][17][18][19][20][21][22] For polymeric Pt(II) complexes, the most investigated drugs are cisplatin and oxaliplatin. The used polymer carriers include chitosan, 23 dendrimers, 24 N-(2-hydroxypropyl) methacrylamide copolymers, 25 polyaspartamide, 26 and polyglutamide polymers.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, enormous efforts have been dedicated to the development of polymeric Pt complexes . These efforts are expected to overcome the side effects by prolonging the systematic circulation and to target drugs to tumor sites via passive and active targeting …”

Section: Introductionmentioning

confidence: 99%

Complex of cisplatin with biocompatible poly(ethylene glycol) with pendant carboxyl groups for the effective treatment of liver cancer

Liu

et al. 2014

J of Applied Polymer Sci

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Cisplatin was incorporated into polymeric carriers through the coordination of Pt with the carboxylic groups of methoxypoly(ethylene glycol) (mPEG)-block-poly[(2-carboxy-ethylsulfanyl)-propyl glycidyl ether] (PCPGE). The mPEG-b-PCPGE/Pt complexes with a Pt content of 14 wt % could self-assemble into spheric micelles with diameter of about 80 nm in aqueous solution. The effective internalization of the polymer platinum micelles by the cells via an endocytosis mechanism was confirmed by confocal laser scanning microscopy and flow cytometry. The antitumor activity of the polymeric micelles was similar to that of cisplatin in vitro. The in vivo blood clearance of platinum was studied, and the results show that the micelles exhibited longer blood circulation than the free cisplatin. The biodistribution of cisplatin and its micelles in mice was studied through the measurement of the Pt content in plasma, organs, and tumors, especially in tumor cell DNA. Their antitumor activity in vivo, assessed in mice bearing H22 liver cancers, showed that the micelles exhibited greater antitumor efficacy than free cisplatin. Therefore, this polymer platinum micelle is a promising candidate as a smart antitumor drug carrier for malignancy therapy in future clinical applications.

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432 Comparison of Efficiency and Side Effect of Adriamycin and Doxetaxel and Adriamycin, Cyclophosphamide and Paclitaxel in Patients with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy

Cited by 4 publications

References 0 publications

Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models

Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models

Preparation and Characterization of Paclitaxel Palmitate Albumin Nanoparticles With High Loading Efficacy: an in Vitro and in Vivo Anti-tumor Study in Mouse Models

Complex of cisplatin with biocompatible poly(ethylene glycol) with pendant carboxyl groups for the effective treatment of liver cancer

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