44gSc production using a water target on a 13MeV cyclotron

Cyclotron production of high purity 44m,44 Sc with deuterons from 44 CaCO 3 targets

“…The most suitable conditions have been identified as a metal-toligand ratio of 1:3 in acetate buffer at pH = 4, and heating the mixture at 70°C for 20 minutes provided the best labeling yields N95%. These values were in agreement with previous studies performed on 46 Sc-DOTA [12,41], 44 Sc-DOTATOC and 44 Sc-DOTATATE with eluted from 44 Ti generator [1,44]. All studies have evidenced that the specific activity was not the major parameter for radiolabelling by DOTA, but was of major importance for further use with biological vectors.…”

“…44 Sc was separated from the irradiated calcium target using the procedure reported previously. The efficiency of our separation method is 88 ± 3%, which is consistent with the previously reported procedures using DGA® resin [41,42]. Radionucleidic analysis through gamma spectrometry showed that the final solutions contained only 44,44m Sc.…”

“…ICP-AES analyses of the eluates gave a value under the detection limit for stable scandium resulting in a specific activity higher than 50 MBq/μmol. This value was significantly lower than the one obtained by Hoehr et al [41] (1400 MBq/μmol), but higher values are expected by increasing produced activities. Moreover the calcium content in the purified samples was under detection limit even if this last one was not the most significant competitive element for complexation by DOTA.…”

“…The other major metallic contaminants were Fe and Al. The total concentration of both elements was 1.14 ± 0.66 ppm, which was lower than the one determined by Severin and Hoehr [7,41]. As DOTA ligands used for radiolabelling is not really specific complexing agents, the total concentration of metallic impurities is a key factor for radiolabelling yield and the total concentration of DOTA.…”

Dependence of 18F Production Yield and Radioactive Impurities on Proton Irradiation Dose

“…Proton beams generated from cyclotrons have been widely employed to produce radionuclides relevant for medical applications [6][7][8] as well as materials studies [9,10].…”