460 Comparison Between Cardiac Magnetic Resonance Imaging And Cardiac Computed Tomography For Quantification Of Myocardial Extracellular Volume Fraction: A Meta-analysis

Han, Dong-Sun; Lin, A.; Gransar, H.; Dey, D.; Friedman, J.; Berman, D.; Tamarappoo, B.

doi:10.1016/j.jcct.2022.06.065

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The control cohort was not included in the mortality analysis due to its significantly lower age and short duration of follow-up. The focus of the outcome analysis was the effect of fibrosis on outcome; therefore, patients with dual pathology AS-ATTR were excluded (this is unique to other ECV CT studies 9 ); this cohort per se was too small to make any inferences about mortality.…”

Section: Methodsmentioning

confidence: 99%

Regional Distribution of Extracellular Volume Quantified by Cardiac CT in Aortic Stenosis: Insights Into Disease Mechanisms and Impact on Outcomes

Patel,

Scully,

Saberwal

et al. 2024

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

BACKGROUND: Extracellular volume fraction (ECV) is a marker for myocardial fibrosis and infiltration, can be quantified using cardiac computed tomography (ECV CT ), and has prognostic utility in several diseases. This study aims to map out regional differences in ECV CT to obtain greater insights into the pathophysiological mechanisms of ECV expansion and its clinical implications. METHODS: Three prospective cohorts were included: patients with aortic stenosis (AS) and coexisting AS and transthyretin cardiac amyloidosis were referred for a transcatheter aortic valve replacement and had ECG-gated CT angiography and Technetium-99m-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy to differentiate between the 2 cohorts. Controls had CT angiography and cardiac magnetic resonance demonstrating no significant coronary artery disease or infarction. Global and regional ECV CT was analyzed, and its association with mortality was assessed for patients with AS. RESULTS: In 199 patients, controls (n=65; 66% male), AS (n=115), and coexisting AS and transthyretin cardiac amyloidosis (n=19) had a global ECV CT of 26.1 (25.0–27.8%) versus 29.1 (27.5–31.1%) versus 37.4 (32.5–46.6%), respectively; P <0.001. Across cohorts, ECV CT was higher at the base (versus apex), the inferoseptum (versus anterolateral wall), and the subendocardium (versus subepicardium); P <0.05 for all. Among patients with AS, epicardial ECV CT , rather than any other regional value or global ECV CT , was the strongest predictor of mortality at a median of 3.9 (max 6.3) years (adjusted hazard ratio, 1.21 [95% CI, 1.08–1.36]; P =0.002). CONCLUSIONS: Regional differences in ECV CT suggest a predilection for fibrosis and amyloid infiltration at the base, subendocardium, inferior wall, and septum more than the anterior and lateral myocardium. ECV CT can predict long-term mortality with the subepicardium demonstrating the strongest discriminatory power. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifiers: NCT03029026 and NCT03094143.

show abstract

Section: Methodsmentioning

confidence: 99%

Regional Distribution of Extracellular Volume Quantified by Cardiac CT in Aortic Stenosis: Insights Into Disease Mechanisms and Impact on Outcomes

Patel,

Scully,

Saberwal

et al. 2024

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

show abstract

“…However, recent innovative research has highlighted the substantial potential within CT, including the ability to assess ECV by CT (ECV CT ), which, indeed, correlates well with ECV from CMR. 8 The ECV CT protocol involves, besides the routine arterial phase, 2 additional acquisitions: first, a native CT before the injection of iodine contrast; second, late images for ECV CT analysis, typically scanned 3 to 10 minutes after arterial phase contrast injection. 9 The ECV CT is calculated based on the rate of change in Hounsfield Units in the myocardium relative to blood, before and after contrast, adjusted for hematocrit.…”

mentioning

confidence: 99%

Advancements in CT Tissue Characterization: Myocardial Insights in Aortic Stenosis and Amyloidosis

Gräni

2024

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

460 Comparison Between Cardiac Magnetic Resonance Imaging And Cardiac Computed Tomography For Quantification Of Myocardial Extracellular Volume Fraction: A Meta-analysis

Cited by 2 publications

References 0 publications

Regional Distribution of Extracellular Volume Quantified by Cardiac CT in Aortic Stenosis: Insights Into Disease Mechanisms and Impact on Outcomes

Regional Distribution of Extracellular Volume Quantified by Cardiac CT in Aortic Stenosis: Insights Into Disease Mechanisms and Impact on Outcomes

Advancements in CT Tissue Characterization: Myocardial Insights in Aortic Stenosis and Amyloidosis

Contact Info

Product

Resources

About