Abstract:Inclisiran is a synthetic small-interfering RNA (siRNA) that works with the RNA interference (RNAi) mechanism. SiRNA binds its target mRNA, leading to silencing the protein synthesis by the related mRNA degradation. Inclisiran is designed to bind solely PCSK9 mRNA, decreasing PCSK9 expression, thus leading to lower LDL-C level. Several chemical modifications were added to obtain a stable compound delivering a rapid effect and generally well tolerated [Khvorova A. Oligonucleotide therapeutics—a new class of cho… Show more
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