5.2 Gamma-Aminobutyric Acid as a Biomarker in Adolescent Depression: A Longitudinal Study

Kufert, Yael; Mehra, Lushna M.; DeWitt, Samuel J.; Xu, Junqian; Gabbay, Vilma

doi:10.1016/j.jaac.2018.09.297

Cited by 1 publication

(3 citation statements)

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“…Although this is only a preliminary study, the analysis and research on the level of GABA further confirmed the relationship between the imbalance of GABA in the brain and MDD, which has certain research value for the timely diagnosis of major depression in adolescents [20,22].…”

Section: The Inhibitory Neurotransmitter Gamma-aminobutyric Acidmentioning

confidence: 64%

“…The study in this article was based on a population of adolescents with MDD [20]. Prior to this research, numerous studies have linked dysregulation of the main inhibitory neurotransmitter gammaaminobutyric acid (GABA) in the brain to the pathophysiology of major depressive disorder [21].…”

Section: The Inhibitory Neurotransmitter Gamma-aminobutyric Acidmentioning

confidence: 99%

“…Prior to this research, numerous studies have linked dysregulation of the main inhibitory neurotransmitter gammaaminobutyric acid (GABA) in the brain to the pathophysiology of major depressive disorder [21]. The researchers used linear regression models to determine the relationship between GABA concentrations and MDD severity by collecting data on GABA levels of adolescents who underwent magnetic resonance spectroscopy (MRS) scans 9 months earlier, with follow-up surveys [20].…”

Section: The Inhibitory Neurotransmitter Gamma-aminobutyric Acidmentioning

confidence: 99%

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Recent Blood and Intracranial Molecular Biomarkers to Moderate Depression and Major Depressive Disorder

Zhong¹

2022

HSET

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Depression, especially moderate depression and MDD, brings huge pressure and loss to patients and society through a series of symptoms. However, the current diagnosis of depression is short of objective, quantifiable, and absolute detection techniques. If we can find specific depression molecular biomarkers and high-sensitivity and high-accuracy molecular biomarker detection technology, it can help patients with depression to diagnose and predict earlier. In this paper, the heterogeneous biomolecules of depression are classified into intracranial markers and blood markers, and the biomolecules with representative value are listed. Meanwhile, it analyzes and compares the current popular biological detection technologies, IHC and RNAscope. If the heterogeneous depression biomarkers can be detected by the combination of IHC and RNAscope technology, the accuracy and timeliness of depression diagnosis will be greatly improved, and lay the groundwork for better depression treatments in the future.

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Section: The Inhibitory Neurotransmitter Gamma-aminobutyric Acidmentioning

confidence: 64%

Section: The Inhibitory Neurotransmitter Gamma-aminobutyric Acidmentioning

confidence: 99%

Section: The Inhibitory Neurotransmitter Gamma-aminobutyric Acidmentioning

confidence: 99%

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