5-ALA fluorescence in indeterminate grade gliomas

Müther, Michael; Stummer, Walter

doi:10.3171/2021.10.focvid21196

Cited by 3 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To prevent the underestimation of focal enhancing tumors, using 5-aminolevulinic acid (5-ALA) guided tissue sampling can be advantageous. This technique enhances the precision of biopsy sampling by making tumor cell visibility under uorescence, thereby improving diagnostic accuracy [30].…”

Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of CNS WHO grade 2 Oligodendroglioma in Adult Patients: A single- institution experience

Byeon,

Lee,

Jeon

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose Oligodendrogliomas (ODGs) are a subtype of diffuse lower-grade gliomas with overall survival of >10 years. This study aims to analyze long-term outcomes and identify prognostic factors in patients with WHO grade 2 isocitrate dehydrogenase (IDH)-mutant, 1p19q-codeleted ODG. Methods We retrospectively reviewed 138 adult patients diagnosed with WHO grade 2 IDH-mutant, 1p19q-codeleted ODG who underwent surgical resection or biopsy between 1994 and 2021, analyzing clinical data, treatment details, and outcomes. Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan–Meier analysis. Univariate and multivariate Cox regression analyses were utilized to identify significant prognostic factors. Results In the gross total resection (GTR) group, 63 (45.7%) underwent observation and 5 (3.6%) received postoperative treatment; in the subtotal resection (STR) or biopsy group, 37 (26.8%) were observed and 33 (23.9%) received postoperative treatment. The median PFS and OS were 6.8 and 18.4 years, respectively. Between adjuvant treatment and observation, there was no significant difference in PFS or OS. However, GTR exhibited significantly better PFS and OS compared to STR or biopsy (p = 0.043 and 0.014, respectively). Multivariate analysis revealed that contrast enhancement on MRI was associated with worse PFS (HR = 2.08, p = 0.004) and OS (HR = 5.89, p = 0.001). And the presence of seizures at presentation was associated with improved OS (HR = 0.21, p = 0.002). Conclusion This study underscores favorable long-term outcomes for patients with IDH-mutant, 1p19q-codeleted ODG WHO grade 2. Our findings indicate that GTR plays a crucial role in enhancing PFS and OS in WHO grade 2 ODG.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of CNS WHO grade 2 Oligodendroglioma in Adult Patients: A single- institution experience

Byeon,

Lee,

Jeon

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…To prevent the underestimation of focal enhancing tumors, using 5-aminolevulinic acid (5-ALA) guided tissue sampling can be advantageous. This technique enhances the precision of biopsy sampling by making tumor cell visibility under fluorescence, thereby improving diagnostic accuracy [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of CNS WHO grade 2 oligodendroglioma in adult patients: a single-institution experience

Byeon,

Lee,

Jeon

et al. 2024

Discov Onc

View full text Add to dashboard Cite

Purpose Oligodendrogliomas (ODGs) are a subtype of diffuse lower-grade gliomas with overall survival of > 10 years. This study aims to analyze long-term outcomes and identify prognostic factors in patients with WHO grade 2 ODG. Methods We retrospectively reviewed 138 adult patients diagnosed with 1p/19q co-deleted ODG who underwent surgical resection or biopsy between 1994 and 2021, analyzing clinical data, treatment details, and outcomes. Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan–Meier analysis. Univariate and multivariate Cox regression analyses were utilized to identify significant prognostic factors. Results In the gross total resection (GTR) group, 63 (45.7%) underwent observation and 5 (3.6%) received postoperative treatment; in the non-GTR group, 37 (26.8%) were observed and 33 (23.9%) received postoperative treatment. The median PFS and OS were 6.8 and 18.4 years, respectively. Between adjuvant treatment and observation, there was no significant difference in PFS or OS. However, GTR or STR with less than 10% residual tumor exhibited significantly better PFS and OS compared to PR or biopsy (p = 0.022 and 0.032, respectively). Multivariate analysis revealed that contrast enhancement on MRI was associated with worse PFS (HR = 2.36, p < 0.001) and OS (HR = 5.89, p = 0.001). And the presence of seizures at presentation was associated with improved OS (HR = 0.28, p = 0.006). Conclusion This study underscores favorable long-term outcomes for patients with 1p/19q co-deleted ODG WHO grade 2. Our findings indicate that the EOR plays a crucial role as a significant prognostic factor in enhancing PFS and OS outcomes in WHO grade 2 ODG.

show abstract

“…However, PDT-mediated injury of vessels is not specific and based on destructive effects of singlet oxygen and reactive oxygen species produced by photosensitizes after their photoexcitation [ 57 ]. Therefore, in this work, we used PDT with 5-ALA because this photosensitizer is used in clinical practice for PDT of glioblastoma [ 58 , 59 ]. Recently, we reported that PDT with 5-ALA causes dose- and age-related injuries of cerebral blood vessels leading to an increase in the permeability of blood–brain barrier [ 52 , 60 – 62 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness: the role of the meningeal lymphatics

Oxana,

Alexander,

Inna

et al. 2023

Front. Optoelectron.

View full text Add to dashboard Cite

With the increase in the aging population, the global number of people with Alzheimer’s disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD. Photobiomodulation (PBM) is non-pharmacological approach that has shown very promising results in the therapy of AD in pilot clinical and animal studies. However, the mechanisms of therapeutic effects of PBM for AD are poorly understood. In this study on mice, we demonstrate that photodynamic effects of 5-aminolevulenic acid and laser 635 nm cause reduction of network of the meningeal lymphatic vessels (MLVs) leading to suppression of lymphatic removal of beta-amyloid (Aβ) from the right lateral ventricle and the hippocampus. Using the original protocol of PBM under electroencephalographic monitoring of wakefulness and sleep stages in non-anesthetized mice, we discover that the 7-day course of PBM during deep sleep vs. wakefulness provides better restoration of clearance of Aβ from the ventricular system of the brain and the hippocampus. Our results shed light on the mechanism of PBM and show the stimulating effects of PBM on the brain lymphatic drainage that promotes transport of Aβ via the lymphatic pathway. The effects of PBM on the brain lymphatics in sleeping brain open a new niche in the study of restorative functions of sleep as well as it is an important informative platform for the development of innovative smart sleep technologies for the therapy of AD. Graphical Abstract

show abstract

5-ALA fluorescence in indeterminate grade gliomas

Cited by 3 publications

References 8 publications

Long-term Outcomes of CNS WHO grade 2 Oligodendroglioma in Adult Patients: A single- institution experience

Long-term Outcomes of CNS WHO grade 2 Oligodendroglioma in Adult Patients: A single- institution experience

Long-term outcomes of CNS WHO grade 2 oligodendroglioma in adult patients: a single-institution experience

Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness: the role of the meningeal lymphatics

Contact Info

Product

Resources

About