5. Epidemiology

Ma, Austin; Goto, Yuichiro; Lenfant, Claude; Ha, Tyroler

doi:10.1016/0002-9149(91)90856-g

Cited by 15 publications

(1 citation statement)

References 66 publications

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“…Epidemiological data support the concept that elevated fasting plasma TG concentrations are an independent risk factor for coronary heart disease (CHD) [5][6][7]. Less evidence exists supporting the concept that postprandial lipemia is an independent risk factor for CHD [5,8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Statins on Postprandial Lipemia

Kolovou¹,

Anagnostopoulou²,

Salpea³

et al. 2007

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Several studies showed that postprandial plasma triglyceride (TG) concentrations are higher in patients with coronary heart disease. TG-rich lipoprotein remnants accumulated in the postprandial state are involved in atherogenesis and in events leading to thrombosis. Lipid lowering drugs, such as 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are of significant benefit in the primary and secondary prevention of atherosclerosis. Statins can decrease total cholesterol and low density lipoprotein cholesterol as well as TG concentrations and improve postprandial lipoprotein metabolism. Since abnormal postprandial lipemia is associated with pathological conditions, its treatment is relevant. This review considers the effect of statins on postprandial lipemia.

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Section: Introductionmentioning

confidence: 99%

The Effect of Statins on Postprandial Lipemia

Kolovou¹,

Anagnostopoulou²,

Salpea³

et al. 2007

CDT

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Effect of Antioxidant Vitamins on the Transient Impairment of Endothelium—Dependent Brachial Artery Vasoactivity Following a Single High-Fat Meal

Plotnick

Corretti

Vogel

1997

JAMA

371

105

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Effectiveness of cascade filtration plasmapheresis in two patients affected by familial hypercholesterolemia

Barbagallo

Averna

Dimarco

et al. 1995

J of Clinical Apheresis

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Hypercholesterolemia has been recognised as a primary risk factor for coronary heart disease. Reduction of plasma levels of total and LDL cholesterol has been shown to decrease coronary atherosclerosis. Plasmapheresis represents an useful non-pharmacological tool to treat severe hypercholesterolemias. We have evaluated the effectiveness of a system of plasmapheresis using a cascade filtration method in two young male subjects (aged 16 and 26 years) with homozygous familial hypercholesterolemia. Both showed severe coronary atherosclerosis as determined by angiography. Procedures were performed at intervals of 7 days in each case. We observed a mean reduction of plasma levels of total cholesterol of 59.5% (range 31.0-75.5%); LDL-cholesterol, 61.6% (range 32.6-77.1%); triglycerides, 48.1%; HDL-cholesterol, 31.1%; apo A-I, 30.8%; and apo B, 57.6%. We also noted a reduction of other parameters, such as fibrinogen (49.9%) and Lp(a) (59.9%). At the end of each procedure about 8 g of cholesterol was removed from the total body pool. A decrease of total proteins (26.9%) and albumin (19.6%) was also observed, but this was completely restored before the next apheresis (1 week). These data show the effectiveness of the removal of LDL in a cascade filtration system, which obtains results not very different from other more selective methods. The lack of selectivity is not much of a problem, since it also reduces other risk factors such as Lp(a) and fibrinogen.

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5. Epidemiology

Cited by 15 publications

References 66 publications

The Effect of Statins on Postprandial Lipemia

The Effect of Statins on Postprandial Lipemia

Effect of Antioxidant Vitamins on the Transient Impairment of Endothelium—Dependent Brachial Artery Vasoactivity Following a Single High-Fat Meal

Effectiveness of cascade filtration plasmapheresis in two patients affected by familial hypercholesterolemia

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