2003
DOI: 10.1124/jpet.103.049239
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5-Hydroxytryptamine (5-HT)2 Receptor Involvement in Acute 5-HT-Evoked Scratching but Not in Allergic Pruritus Induced by Dinitrofluorobenzene in Rats

Abstract: We investigated the role of serotonin (5-hydroxytryptamine; 5-HT) 2 and 5-HT 3 receptor subtypes in acute itch-associated scratching behavior as well as in an allergic pruritus model in rats. Intradermal 5-HT evoked hind limb scratching directed toward the injection site in naïve rats. Scratching behavior was significantly reduced by pretreatment with the 5-HT 2 receptor antagonist ketanserin. Intradermal injection of ␣-methylserotonin, a 5-HT 2 receptor agonist, also elicited scratching behavior in a dose-dep… Show more

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Cited by 59 publications
(51 citation statements)
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“…Neither bout duration nor within-bout frequency varied with time or concentration of 5-HT, consistent with our previous study (Nojima and Carstens 2003b). Facial scratch bouts in rats exhibited lower frequency and longer duration compared with facial scratching in mice (12.6 Hz, 0.4 s) (Akiyama et al 2010b), with the difference in frequency likely explained by allometric scaling.…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…Neither bout duration nor within-bout frequency varied with time or concentration of 5-HT, consistent with our previous study (Nojima and Carstens 2003b). Facial scratch bouts in rats exhibited lower frequency and longer duration compared with facial scratching in mice (12.6 Hz, 0.4 s) (Akiyama et al 2010b), with the difference in frequency likely explained by allometric scaling.…”
Section: Discussionsupporting
confidence: 77%
“…Cheek injection of 5-HT was presently found to elicit dose-dependent hindlimb scratching, consistent with previous reports that 5-HT evoked hindlimb scratch bouts directed to the injection site in the nape of the neck in rats (Hachisuka et al 2010;Jinks and Carstens 2002;Carstens 2003a, 2003b;Nojima et al 2003;Thomsen et al 2001Thomsen et al , 2002 and mice (Inagaki et al 2001;Maekawa et al 2000;Yamaguchi et al 1999). Rat mast cells contain higher concentrations of 5-HT than histamine (Purcell et al 1989), possibly related to the scratch-inducing capacity of 5-HT in this species.…”
Section: Discussionsupporting
confidence: 76%
“…Serotonin is a weak pruritogen in human subjects (26) and strongly elicits scratching through 5-HT 2 receptors in mice and rats (16,39). The ESGM-elicited scratching was not suppressed by cyproheptadine that blocks the 5-HT 2 receptor, suggesting that serotonin is not involved in mosquito allergy-associated itching.…”
Section: Discussionmentioning
confidence: 99%
“…The study was approved by the Committee for Animal Experiments at University of Toyama. (14), cimetidine (15), terfenadine (2), and cyproheptadine (16).…”
Section: Animalsmentioning
confidence: 99%
“…Atopic dermatitis model was successfully induced by DNFB, which induces an immune response and elicits an allergic reaction including pruritus as assessed by scratching (Nojima & Carstens, 2003). Treatment efficacy of formulations was evaluated in terms of uniformity of skin barrier function, visual scoring and histological parameters.…”
Section: Treatment Efficacy Of Formulationsmentioning
confidence: 99%