5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomized crossover trial

Abstract

PUVA provides a better short- and long-term response than medium-dose UVA1 in patients with severe AD.

Phototherapy in Atopic Dermatitis: A Systematic Review of the Literature

“…15 The shortest follow-up period was 4 weeks 9,14,20 and the longest periods were 6 months 6,21 and 12 months. 7,17 Several studies had no follow-up period. 10,15,18,19,22---27 In most studies, the outcome measures were changes in scores on clinical scales.…”

“…10,15,18,19,22---27 In most studies, the outcome measures were changes in scores on clinical scales. The most frequently used scales were SCORing Atopic Dermatitis (SCO-RAD) or a modified form of SCORAD, 6,7,9,16,17,19,21,28 Costa's Simple Scoring System (SSS), 10,15,18,27 the Leicester scale, 15,27 and the severity score 29 of Hanifin and Rajka. 23---26 Some studies also used quality-of-life scales (Eczema Disability Index, 17 Sickness Impact Profile 6 ) and assessments of pruritus.…”

“…Before carrying out the online searches, we identified 2 articles that met the inclusion criteria and were expected to be retrieved by the searches in all of the databases. 6,7 The search strategies will be provided on request by the corresponding author.…”

Phototherapy for atopic dermatitis

“…[15] In a large randomised controlled trial, Heinlin et al observed that synchronous balneo phototherapy with NB-UVB was significantly better than NB-UVB alone for the reduction of SCORAD at the end of the treatment period (P < 0.004) and at 6 months (P < 0.04; Level of evidence 1++). [33] UVA-1 phototherapy In a pilot study of UVA-1 irradiation, Krutman et al compared UVA-1 phototherapy (given in a single dose of 130J /cm 2 for 15 consecutive days) with UVA/B irradiation (starting doses 30 mJ/cm 2 UVB and 7 J/cm 2 UVA, respectively). [34] The authors found UVA-1 to be significantly more effective compared with UVA/B therapy in reducing the clinical scores and in the downregulation of eosinophilic cationic protein levels.…”

Current Approach to Phototherapy Applications in Dermatology Practice: Part 2. Phototherapy in Vitiligo, Mycosis Fungoides, Atopic Dermatitis, Sclerosing Diseases and Psoriasis

“…Bu çalışmanın başka bir önemli sonucu da, tedavi sonrası ortanca remisyon süresinin UVA1'de sadece dört hafta, PUVA'da ise 12 hafta olmasıdır. Bu sonuçlar, PUVA'nın UVA1'den daha etkili olduğunu ve dar bant UVB'ye yeterince yanıt vermeyen hastalarda alternatif olabileceğini göstermiştir (65). Şiddetli kronik AD'de, sağ-sol karşılaştırmalı bir dizaynla, 8-MOP banyo PUVA ile dar bant UVB'nin karşılaştırıldığı bir çalışmada, hastalık şiddet skorunda azalma banyo PUVA'da %65,7, dar bant UVB'de %64,1 olarak bulunmuştur.…”