“…Among five membered heterocycles, pyrazoline and imidazole are represents great importance in biological activities like, antidepressant [18], anticonvulsant [19], antimicrobial [20], analgesics [21] and antitumor [22]. In fact, pyrazoline derivative is now widely used in the market as antiinflammatory [23], analgesics [24], antibacterial [25], antifungal [26], antituberculosis [27], anticonvolusant [28] and potential anticytokine agents [29,30]. Recently, some attention has also been focused upon the reactions of hydroxyl substituted chalcones can be O-alkylated under the basic medium with a suitable alkylating agent to give bifunctional bis-chalcones molecules which are formed by liking two chalcone moieties together through the carbon chains of varying length and structures.…”