5 Towards cannabinoid drugs

Mechoulam, Raphael; Feigenbaum, Jeffery J.

doi:10.1016/s0079-6468(08)70422-3

Cited by 36 publications

(33 citation statements)

References 132 publications

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“…In India, Cannabis sativa preparations have been used against vomiting (Mechoulam and Feigenbaum, 1987). Furthermore, Sallan et al (1975) found that the active component of C. sativa have antiemetic property, which reside in its ability to stimulate cannabinoid receptor type 1 (CB 1 ) (Darmani, 2001a).…”

Section: Introductionmentioning

confidence: 99%

Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

Ullah

Subhan²,

Rauf³

et al. 2012

Afr. J. Pharm. Pharmacol.

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Section: Introductionmentioning

confidence: 99%

Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

Ullah

Subhan²,

Rauf³

et al. 2012

Afr. J. Pharm. Pharmacol.

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“…Since then, a number of natural and synthetic compounds with cannabimimetic activity have been identified. These compounds have been highly useful in cannabinoid research (7)(8)(9).…”

mentioning

confidence: 99%

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

Zimmer

Hohmann

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

968

693

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ABSTRACT⌬ 9 -Tetrahydrocannabinol (⌬ 9 -THC), the major psychoactive ingredient in preparations of Cannabis sativa (marijuana, hashish), elicits central nervous system (CNS) responses, including cognitive alterations and euphoria. These responses account for the abuse potential of cannabis, while other effects such as analgesia suggest potential medicinal applications. To study the role of the major known target of cannabinoids in the CNS, the CB1 cannabinoid receptor, we have produced a mouse strain with a disrupted CB1 gene. CB1 knockout mice appeared healthy and fertile, but they had a significantly increased mortality rate. They also displayed reduced locomotor activity, increased ring catalepsy, and hypoalgesia in hotplate and formalin tests. ⌬ 9 -THC-induced ring-catalepsy, hypomobility, and hypothermia were completely absent in CB1 mutant mice. In contrast, we still found ⌬ 9 -THC-induced analgesia in the tail-f lick test and other behavioral (licking of the abdomen) and physiological (diarrhea) responses after ⌬ 9 -THC administration. Thus, most, but not all, CNS effects of ⌬ 9 -THC are mediated by the CB1 receptor.

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“…Tetrahydrocannabinol (THC) enhance appetite in acquired immune deficiency syndrome (AIDS) patients (4), which can be equated with ancient Ma-fen use for waste diseases and injuries; cannabinoids also provide neuroprotection (5) and are well known to reduce temperature (6). A recent paper described the effects of cannabidiol (CBD), a major cannabis constituent, in collagen-induced arthritis in mice (7), which obviously fits with the ancient use of cannabis for 'rheumatism'.…”

Section: Ma-fen Is Used For Waste Diseases and Injuries; It Clears Blmentioning

confidence: 99%

“…The level of psychotropic activity almost always paralleled that of the potential therapeutic effects. Nevertheless, THC was approved by regulatory authorities in several countries, including the United States, for use in two medical conditions: for nausea and vomiting due to anticancer treatment, and in appetite promotion (4). A psychotropic cannabinoid, nabilone, which parallels THC in most of its actions but is considerably more potent, is used in the United Kingdom and in Switzerland (30).…”

Section: Thc As An Antiemetic Drugmentioning

confidence: 99%

The Cannabinoids: An Overview. Therapeutic Implications in Vomiting and Nausea after Cancer Chemotherapy, in Appetite Promotion, in Multiple Sclerosis and in Neuroprotection

Mechoulam

Hanŭs

2001

Pain Research and Management

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The present paper describes the historical use of cannabis, starting with its use in Assyria and China. Recent advances in the understanding of the molecular basis of cannabis action are explained, including the identification of the cannabinoid receptors CB 1 and CB 2 , as well as the isolation of endogenous cannabinoids from the brain and periphery. The use of delta 9 -tetrahydrocannabinol as an antivomiting and antinausea drug for cancer chemotherapy, and as an appetite-enhancing agent is described. Clinical work in multiple sclerosis, which may lead to the approval of tetrahydrocannabinol as a drug for this condition, is presented. Preclinical and clinical investigations with cannabidiol, a nonpsychotropic cannabis constituent, are also described. Recent work with cannabidiol in animal models of rheumatoid arthritis may lead to clinical investigations. A synthetic cannabinoid, HU-211 (Dexanabinol), is in advanced clinical stages of investigation as a neuroprotectant in head trauma. The above clinical approaches may ultimately lead to the realization that cannabinoids are valuable clinical drugs in numerous fields.

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5 Towards cannabinoid drugs

Cited by 36 publications

References 132 publications

Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

The Cannabinoids: An Overview. Therapeutic Implications in Vomiting and Nausea after Cancer Chemotherapy, in Appetite Promotion, in Multiple Sclerosis and in Neuroprotection

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