59. The effect of cold exposure on adipocytes: Examining a novel method for the non-invasive removal of fat

Cooling for fat

“…Following treatment, it is likely that the first effect after cold exposure is apoptosis or necrosis of the adipocytes. In animal studies, adipocytes cooled to temperatures of −2, 0, and 2 ∘ C underwent apoptosis or necrosis; the majority of adipocytes cooled to temperatures less than 7 ∘ C also underwent apoptosis or necrosis [6]. Adipocytes cooled to temperatures between 14 and 28 ∘ C did not show these effects.…”

Non‐invasive cryolipolysis™ for subcutaneous fat reduction does not affect serum lipid levels or liver function tests

“…Adipocytes suffer a fatal apoptotic injury when exposed to cold, as demonstrated by studies on cultured samples [3]. Clinical studies showed that non-invasive cooling to initiate adipocyte death leads to a reduction in fat layer thickness that is evident in ultrasound measurements and visible to the eye [4][5][6].…”

Contrast lipocryolysis

“…One of these new technical developments is the second generation of lipocryolysis, also known as contrast lipocryolisis, which has already proved to be effective in in vitro adipocyte models 3 . Apoptotic adipocytolysis as a consequence of intracellular changes was the first and most logical action mechanism proposed for lipocryolysis 1 , 8 - 10 . It was assumed that adipocytolysis was the biological consequence of intracellular lipid crystallization.…”