Recently, there have been notable advancements in wireless communication systems to address the deficiencies of fourth generation (4G) wireless technology, such as insufficient spectrum bandwidth, slow data transfer rates, and constrained network capacity. These issues may be addressed in fifth generation (5G) wireless technology, which is no longer stand-alone. This article proposes and designs a defected ground slotted patch antenna (DGSPA) for 5G (Sub-6 GHz band) applications. It can work at 3.5 GHz in the 5G N77 band, Sub-6 GHz 5G, LTE Band 42, and WiMAX. The suggested antenna has an overall dimension of 38×38×1.575 mm3 and is built on the Rogers RT5880 substrate material, whose dielectric permittivity is 2.2. The CST software is used as the simulation tool to analyze the designed antenna’s performance. The novelty of the recommended antenna is in terms of its small size with defective ground structure (DGS), high antenna gain, perfect impedance matching, and improved impedance bandwidth. The role of the DGS is evaluated by comparing the antenna’s performance with and without the DGS. It has been noticed that the DGS-backed antenna had an impedance bandwidth improvement of more than 11MHz, whereas the impedance profile is (50.086−????0.179) Ω, which denotes 50 Ω pure resistivity. It will operate within the frequency range of (3.4828 - 3.522) GHz with an impedance bandwidth of 69.2 MHz. The proposed antenna’s reflection coefficient (|????1,1|) is obtained as -54.028 dB at the resonating frequency of 3.5176 GHz, whereas the radiation gain and efficiency are observed as 6.463 dB and 93.475%, respectively. Thus, due to its promising performance based on radiation pattern, optimum efficiency, and higher bandwidth, the recommended defected ground slotted patch antenna can efficiently be used for the application of Sub-6 GHz 5G services.