6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity

Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity

“…In order to compare the cytotoxic effects of studied compounds in their free state, the cytotoxicity of surfactants was assessed by standard MTT assay on noncancerous Chinese hamster ovary cells (CHO‐K1) that have been used previously for the cellular toxicity evaluation of quaternary ammonium compounds . Importantly, the newly synthesized POSAB (see Figure S1‐S3 for 1 H NMR, 13 C NMR and HRMS spectra) showed considerably lower or minimal cytotoxicity when compared to CTAB or MTAB (see Table and Figure S4).…”

“…Quaternary ammonium salts (QAS) are common chemical reagents widely used in pharmacy, organic chemistry and industry especially as antibacterial, antiviral and antifungal compounds . Positively charged quaternary ammonium heads interact with negatively charged cellular membranes of both Gram‐positive and Gram‐negative bacterial cells leading to its destruction and leakage of intracellular components .…”

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

“…52 The observed toxicity was expressed as LC 50 values ( Table 2). The majority of the compounds showed very low levels of toxicity with an LC 50 value over 200 µM compared to parent frentizole, producing valuable results for further investigation.…”

“…The cells were cultured according to ECACC recommended conditions and seeded in a density of 8000 per well as was described earlier. 52 Briefly, tested compounds were dissolved in DMSO and subsequently in the growth medium (F-12) supplemented with 10% FBS and 1% PEN/STREP so that the final concentration of DMSO did not exceed 0.5% (v/v). Cells were exposed to the tested compounds in the medium (100 µL) for 24 hours.…”

6-Benzothiazolyl Ureas, Thioureas and Guanidines are Potent Inhibitors of ABAD/17β-HSD10 and Potential Drugs for Alzheimer"s Disease Treatment: Design, Synthesis and in vitro Evaluation

“…The protocol for this assay has been described previously [36]. Briefly CHO cell line (Chinese hamster ovary, CHO-K1WT2, CRL-1984 ECACC, Salisbury, UK) were cultured according to ECACC recommended conditions and seeded in a density of 8 000 cells per well as was described earlier [37]. Tested compounds were dissolved in DMSO and subsequently in the growth medium (F-12)…”