608 A new multifunctional drug delivery system based on polymalic acid to inhibit angiogenesis and invasion of human gliomas in vitro and in vivo

Ljubimova, Julia Y.; Holler, Eggehard; Fujita, Manabu; Khazenzon, Natalya M.; Lee, B.; Black, Kvar

doi:10.1016/s1359-6349(04)80616-5

European Journal of Cancer Supplements

2004

DOI: 10.1016/s1359-6349(04)80616-5

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608 A new multifunctional drug delivery system based on polymalic acid to inhibit angiogenesis and invasion of human gliomas in vitro and in vivo

Julia Y. Ljubimova¹,

Eggehard Holler²,

Manabu Fujita³

et al.

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2012

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Antisense Molecular Therapy in Cerebral Gliomas

Caruso

2012

J. Anal. Oncol.

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Despite innovative therapeutic strategies, the expectative of life in patients affected by cerebral gliomas remain dismal. Malignant gliomas represent a class of infiltrative and aggressive neoplasms that are generally resistant to multimodal approach. The efficacy of classical anti-cancer strategies is seriously limited by lack of specific therapies against malignant cells.Glial tumors seem to be able to create a favorable environment for the invasion of glioma cells in cerebral parenchyma when they combine with the extracellular matrix via cell surface receptors. Recent advances in molecular and tumor biology have lead to a new class of modern antitumoral agents. Antisense oligonucleotides are synthetic stretches of DNA which hybridize with specific mRNA strands. The specificity of hybridization makes antisense method an interesting strategy to selectively modulate the expression of genes involved in tumorigenesis. In this review, molecular targets, clinical and experimental studies about the use of antisense oligonucleotides in cerebral gliomas treatment are reported.

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Antisense Molecular Therapy in Cerebral Gliomas

Caruso

2012

J. Anal. Oncol.

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608 A new multifunctional drug delivery system based on polymalic acid to inhibit angiogenesis and invasion of human gliomas in vitro and in vivo

Cited by 1 publication

References 0 publications

Antisense Molecular Therapy in Cerebral Gliomas

Antisense Molecular Therapy in Cerebral Gliomas

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