65-Year-Old Woman With Chronic Eosinophilia

Hujoel, Isabel A.; Jaeger, Thomas M.

doi:10.1016/j.mayocp.2017.05.031

Cited by 1 publication

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A systematic approach with the patients' presenting features serving as a guide would be pragmatic. 10 A detailed history including drugs, travel history and allergies is mandatory, as many studies implicate intake of herbal medication in eosinophilia. 10,11 Various parasites such as Strongyloides stercoralis, Ankylostoma duodenale, Schistosoma species etc may cause eosinophilia and must be ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…10 A detailed history including drugs, travel history and allergies is mandatory, as many studies implicate intake of herbal medication in eosinophilia. 10,11 Various parasites such as Strongyloides stercoralis, Ankylostoma duodenale, Schistosoma species etc may cause eosinophilia and must be ruled out. 3,10,12 A diagnosis of CEL can be made if there is evidence of clonality or increased blasts in the peripheral blood/bone marrow, while IHES is a diagnosis of exclusion.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Various parasites such as Strongyloides stercoralis, Ankylostoma duodenale, Schistosoma species etc may cause eosinophilia and must be ruled out. 3,10,12 A diagnosis of CEL can be made if there is evidence of clonality or increased blasts in the peripheral blood/bone marrow, while IHES is a diagnosis of exclusion. 13 The current WHO guidelines gives weightage to cytogenetic and molecular studies as its primary criteria without a definite outline for morphologic criteria.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Persistent Eosinophilia: A Diagnostic Dilemma

Shabeer

Mannem

Ramdas

et al. 2020

APALM

View full text Add to dashboard Cite

Chronic eosinophilic leukaemia-not otherwise specified (CEL-NOS) is a myeloproliferative neoplasm associated with an autonomous, clonal proliferation of eosinophilic precursors resulting in persistent eosinophilia.A 50-year-old female presented with easy fatiguability, cough and generalised swelling of the body. Investigations revealed anaemia with leucocytosis (56.150 x 103/ul) and 88% eosinophils (absolute eosinophil count was 49412/ul). Peripheral smear showed abnormal eosinophils exhibiting abnormal granulation and nuclear lobation. Reactive causes were ruled out and a bone marrow aspiration/biopsy revealed mildly hypercellular marrow with increased number of eosinophils and their precursors, 7% blasts along with dysplastic megakaryocyteshypolobated and occasional segmented forms. Molecular studies including chromosomal and gene analysis were done. A combination of the clinical picture, laboratory and molecular studies led us to a diagnosis of CEL-NOS.The causes for eosinophilia are myriad and range from reactive causes like parasitic infestations to neoplasms in which eosinophils are a part of the neoplastic population/ are cytokine-mediated reactive component in the background of another neoplasm.The incidence of CEL-NOS is obscure due to significant overlap with Idiopathic Hypereosinophilic Syndrome (IHES). While CEL-NOS is a myeloproliferative neoplasm and its diagnosis can be made provided evidence of a clonality is present, IHES is a diagnosis of exclusion. It is important to differentiate the two entities as they carry different prognosis and modes of treatment.

show abstract

Section: Discussionmentioning

confidence: 99%