68Ga–Prostate-Specific Membrane Antigen PET/CT Uptake in Intraventricular Meningioma in the Choroid Plexus

Abstract

A 68-year-old man in whom a prostate cancer biochemical recurrence was being investigated was referred for a full-body 68Ga–prostate-specific membrane antigen PET/CT. Focal uptake in a lesion on the choroid plexus projection was detected. Patient had no neurological complaints. A previous MRI performed 4 years ago showed the same lesion. According to the location and radiological and clinical characteristics, the diagnosis of meningioma was defined. The interpretation of prostate-specific membrane antigen PET/CT must take into account the low frequency of metastases in sites such as the central nervous system, and the possibility of intense uptake in lesions unrelated to prostate cancer.

Elevated 68Ga-FAPI Uptake by Primary Benign Intraosseous Meningioma

“…Primary intraosseous meningioma should be differentiated from osteosarcoma, 4 Ewing sarcoma, 5 metastases, 6 and xanthomas 7 . Many studies suggested that meningioma can cause increased uptake of various radiotracers, including 18 F-FDG, 3 68 Ga-DOTATATE, 8 68 Ga-PSMA, 9 18 F-FLT, 10 18 F-florapronol, 11 and so on. 68 Ga-labeled FAPI has recently been introduced as a promising tumor imaging agent, which has shown promising results in the diagnosis of cancer and inflammatory diseases 12–14 .…”

Incidental prostate-specific membrane antigen-avid meningioma detected on 68Ga–prostate-specific membrane antigen PET/CT

“…In routine PSMA imaging, normal brain parenchyma does not demonstrate significant PSMA uptake which provides a suitable background and contributes to the sensitivity for the detection of these various brain pathologies. 17 , 20 Our case report adds to the existing literature of cases of meningioma showing 68 Ga-PSMA uptake [ [21] , [22] , [23] , [24] ].…”

Incidental Meningioma With Altered PSMA Expression After Systemic Hormone Therapy and Local Radiotherapy Detected by 68Ga-PSMA PET/CT

“…3,4 There are also several reports demonstrating 68 Ga-PSMA uptake in meningiomas on PSMA-targeted PET/CT. [5][6][7][8] However, to the best of our knowledge, this is the first report demonstrating the progression of 68 Ga-PSMA uptake in cranial meningioma by PET/CT imaging in a patient receiving hormone therapy. PET/CT images (D-E) obtained after RT (54 Gy, 1.8 Gy per fraction) administered to this lesion in the interval period revealed a partial regression of PSMA expression.…”

“…In the literature, it has been reported that meningiomas may contain hormone receptors such as gonadotropin-releasing hormone or progesterone, and therefore these lesions may enlarge in patients treated with LH-RH agonist 3,4. There are also several reports demonstrating 68 Ga-PSMA uptake in meningiomas on PSMA-targeted PET/CT [5][6][7][8]. However, to the best of our knowledge, this is the first report demonstrating the progression of 68 Ga-PSMA uptake in cranial meningioma by PET/CT imaging in a patient receiving hormone therapy.…”