Brain Edema IX 1994
DOI: 10.1007/978-3-7091-9334-1_135
|View full text |Cite
|
Sign up to set email alerts
|

7.2% NaCl/10% Dextran 60 versus 20% Mannitol for Treatment of Intracranial Hypertension

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
16
0
3

Year Published

2003
2003
2016
2016

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 24 publications
(19 citation statements)
references
References 31 publications
0
16
0
3
Order By: Relevance
“…Most common and notable electrolyte derangements are serum sodium and potassium levels following a head injury [23] Changes in fluid level secondary to resuscitative measures and pharmacological therapy (use of Furosemide and Mannitol) [24] are mainly responsible for these. Volume replacement with isotonic fluids not only is therapeutically of limited efficacy but may aggravate posttraumatic brain edema [25]. Same were the causes in our study and we also experienced difficulty in maintaining fluid balance.…”
Section: Discussionmentioning
confidence: 54%
“…Most common and notable electrolyte derangements are serum sodium and potassium levels following a head injury [23] Changes in fluid level secondary to resuscitative measures and pharmacological therapy (use of Furosemide and Mannitol) [24] are mainly responsible for these. Volume replacement with isotonic fluids not only is therapeutically of limited efficacy but may aggravate posttraumatic brain edema [25]. Same were the causes in our study and we also experienced difficulty in maintaining fluid balance.…”
Section: Discussionmentioning
confidence: 54%
“…The therapeutic effect of HTS on ICP lasted up to 500 min, whereas the mannitol treated animals' ICP returned to overshoot the baseline ICP by 10%-25% within 120 min (P Ͻ 0.01). Berger et al (55) administered a single osmotic load of 7.5% HTS/10% dextran-60 or 20% mannitol to rabbits with cryogenicinduced focal brain injury. The mannitol group had lower mean arterial blood pressure (MAP), pH value, and Pao 2 and a higher Paco 2 .…”
Section: Hts Versus Mannitolmentioning
confidence: 99%
“…With each administration of 10 mg/kg dantrolene, mannitol was coadministered at 165 mg/kg; the total osmolarity of the injected solution was approximately 288 mosm, which is relatively isotonic. In studies showing reduced edema and neuroprotection by mannitol, dosages typically range between 1.0 -1.5 g/kg and produce a hypertonic bolus (e.g., Filbert et al, 1993;Ueno et al, 1994;Berger et al, 1994;Bareyre et al, 1997;Korenkov et al, 2000). However, mannitol has been reported to possess free radical scavenging properties (e.g., Willis et al, 1994;Jiang et al, 2001;Larsen et al, 2002) which may have provided an extra measure of neuroprotection.…”
Section: Discussionmentioning
confidence: 99%