7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice

Rawlings-Mortimer, Florence; Lazari, Alberto; Tisca, Cristiana; Tachrount, Mohamed; Martins-Bach, Aurea B.; Miller, Karla L.; Lerch, Jason P.; Johansen‐Berg, Heidi

doi:10.3389/fnsys.2023.1134594

Cited by 3 publications

(1 citation statement)

References 69 publications

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“…After waiting for the distribution of fisetin, 20 min ECoG recording was taken in the same procedure. While determining the acute drug doses applied in the study, an average value was chosen based on the studies in the literature (17)(18)(19). After all procedures, animals were decapitated.…”

Section: Experimental Design and Applicationmentioning

confidence: 99%

Flavonoidlerin Beyin Fonksiyonu Üzerindeki Potansiyellerini Keşfetmek: Üç Fenolik Bileşiğin Beyin Elektriksel Aktivitesi Üzerindeki Etkileri

ÖZTÜRK,

BAŞOĞLU,

ABİDİN

et al. 2023

Harran Üniversitesi Tıp Fakültesi Dergisi

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Background: The most common polyphenolic compounds taken up by the organism through the food chain are flavonoids. Known to cross the blood-brain barrier, 7,8-DHF, L-theanine and Fisetin are re-ported to have neuronal effects as well as therapeutic potential for neurodegenerative diseases. How-ever, little is known on their acute effects of neuronal function. This study aims to describe the effects of the mentioned flavonoids on the total ECoG activities and band analyzes of healthy mice. Materials and Methods: For this purpose, 3 different groups consisting of 7 subjects were created for each flavonoid administration. After the baseline electrophysiological recordings, flavonoid administra-tion was performed and acute effects were determined. Results: 7.8-DHF increased the theta, alpha and beta band activities while decreasing the total ECoG power. L-theanine and Fisetin did not significantly alter the total ECoG activity. However, L-theanine statistically increased theta, alpha and beta band activities. Conclusions: In conclusion, our data showed that flavonoids could acutely modulate the ECoG respons-es in a band specific manner. They can be considered as candidate molecules for drug discovery studies for central nervous system disorders.

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Section: Experimental Design and Applicationmentioning

confidence: 99%

Flavonoidlerin Beyin Fonksiyonu Üzerindeki Potansiyellerini Keşfetmek: Üç Fenolik Bileşiğin Beyin Elektriksel Aktivitesi Üzerindeki Etkileri

ÖZTÜRK,

BAŞOĞLU,

ABİDİN

et al. 2023

Harran Üniversitesi Tıp Fakültesi Dergisi

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Enhancement of response learning in male rats with intrastriatal infusions of a BDNF - TrkB agonist, 7,8-dihydroxyflavone

Gardner,

Ambalavanar,

Gold

et al. 2024

Preprint

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Enhancement of learning and memory by cognitive and physical exercise may be mediated by brain-derived neurotrophic factor (BDNF) acting at tropomyosin receptor kinase B (TrkB). Upregulation of BDNF and systemic administration of a TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), enhance learning of several hippocampus-sensitive tasks in rodents. Although BDNF and 7,8-DHF enhance functions of other brain areas too, these effects have mainly targeted non-cognitive functions. One goal of the present study was to determine whether 7,8-DHF would act beyond the hippocampus to enhance cognitive functions sensitive to manipulations of the striatum. Here, we examined the effects of intrastriatal infusions of 7,8-DHF on learning a striatum-sensitive response maze and on phosphorylation of TrkB receptors in 3-month-old male Sprague Dawley rats. Most prior studies of BDNF and 7,8-DHF effects on learning and memory have administered the drugs for days to months before assessing effects on cognition. A second goal of the present study was to determine whether a single drug treatment near the time of training would effectively enhance learning. Moreover, 7,8-DHF is often tested for its ability to reverse impairments in learning and memory rather than to enhance these functions in the absence of impairments. Thus, a third goal of this experiment was to evaluate the efficacy of 7,8-DHF in enhancing learning in unimpaired rats. In untrained rats, intrastriatal infusions of 7,8-DHF resulted in phosphorylation of TrkB receptors, suggesting that 7,8-DHF acted as a TrkB agonist and BDNF mimic. The findings that a single, intra-striatal infusion of 7,8-DHF 20 min before training enhanced response learning in rats suggest that, in addition to its trophic effects, BDNF modulates learning and memory through receptor mediated cell signaling events.

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Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

Szulc,

Wiśniewska,

Żabińska

et al. 2024

Foods

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Over the past decades, there has been a significant increase in the burden of neurological diseases, including neurodegenerative disorders, on a global scale. This is linked to a widespread demographic trend in which developed societies are aging, leading to an increased proportion of elderly individuals and, concurrently, an increase in the number of those afflicted, posing one of the main public health challenges for the coming decades. The complex pathomechanisms of neurodegenerative diseases and resulting varied symptoms, which differ depending on the disease, environment, and lifestyle of the patients, make searching for therapies for this group of disorders a formidable challenge. Currently, most neurodegenerative diseases are considered incurable. An important aspect in the fight against and prevention of neurodegenerative diseases may be broadly understood lifestyle choices, and more specifically, what we will focus on in this review, a diet. One proposal that may help in the fight against the spread of neurodegenerative diseases is a diet rich in flavonoids. Flavonoids are compounds widely found in products considered healthy, such as fruits, vegetables, and herbs. Many studies indicated not only the neuroprotective effects of these compounds but also their ability to reverse changes occurring during the progression of diseases such as Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis. Here, we present the main groups of flavonoids, discussing their characteristics and mechanisms of action. The most widely described mechanisms point to neuroprotective functions due to strong antioxidant and anti-inflammatory effects, accompanied with their ability to penetrate the blood-brain barrier, as well as the ability to inhibit the formation of protein aggregates. The latter feature, together with promoting removal of the aggregates is especially important in neurodegenerative diseases. We discuss a therapeutic potential of selected flavonoids in the fight against neurodegenerative diseases, based on in vitro studies, and their impact when included in the diet of animals (laboratory research) and humans (population studies). Thus, this review summarizes flavonoids’ actions and impacts on neurodegenerative diseases. Therapeutic use of these compounds in the future is potentially possible but depends on overcoming key challenges such as low bioavailability, determining the therapeutic dose, and defining what a flavonoid-rich diet is and determining its potential negative effects. This review also suggests further research directions to address these challenges.

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7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice

Cited by 3 publications

References 69 publications

Flavonoidlerin Beyin Fonksiyonu Üzerindeki Potansiyellerini Keşfetmek: Üç Fenolik Bileşiğin Beyin Elektriksel Aktivitesi Üzerindeki Etkileri

Flavonoidlerin Beyin Fonksiyonu Üzerindeki Potansiyellerini Keşfetmek: Üç Fenolik Bileşiğin Beyin Elektriksel Aktivitesi Üzerindeki Etkileri

Enhancement of response learning in male rats with intrastriatal infusions of a BDNF - TrkB agonist, 7,8-dihydroxyflavone

Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

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