7‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts

Park, Yu‐Kyoung; Yadav, Anil Kumar; Roshanzadeh, Amir; Ryoo, Young Wook; Kim, Bae‐Hwan; Yun, Ji Young; Son, Yeon Kyung; Lee, Na Young; Jang, Byeong‐Churl

doi:10.3892/mmr.2019.10899

Cited by 4 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, H 2 O 2 -induced ROS generation and MMP-1 expression decreased, whereas the expression of pro-collagen type 1 and elastin increased [ 21 ]. When palmitoleic acid is added to UV-B-irradiated HaCaT and human dermal fibroblasts, the expression levels of cyclooxygenase-2, MMP-3, c-Fos, and c-Jun decrease, whereas the expression of type 1 procollagen increases [ 22 ]. This provides a theoretical background for the ability of palmitoleic acid to improve skin elasticity and wrinkle formation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study

Koh

Seok

Park

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study

Koh

Seok

Park

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Inflammation and ROS accumulation have been reported to separately activate MMP expression [46][47][48]. However, as noted above, ROS stimulated the inflammatory process in the skin, whereas activated inflammatory cells such as macrophages produced large quantities of ROS.…”

mentioning

confidence: 90%

Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation

Zhang

et al. 2020

Stem Cell Res Ther

View full text Add to dashboard Cite

Background: Large numbers of adipose-derived stem cells (ADSCs) are easily obtained and have been demonstrated to protect against ultraviolet B (UVB)-induced skin photoaging. Extracellular vesicles (EVs) exhibit some of the same effects as the cells from which they originate and have many advantages over stem cells. In particular, their application circumvents many safety concerns associated with cell therapy. Thus, as a cell-free agent, adipose-derived stem cell extracellular vesicles (ADSC-EVs) have anti-photoaging potential. However, the protective effects of ADSC-EVs in skin photoaging remain uncertain. Methods: To investigate the effect of ADSC-EVs on mice with UVB-induced photoaging, 150 μg and 300 μg ADSC-EVs were subcutaneously injected weekly into photoaging mice for 8 weeks. The protective effect was evaluated by gross assessment and hematoxylin and eosin, Masson's trichrome, and β-galactosidase staining. Proliferating cell nuclear antigen, CD68, and dihydroethidium staining were performed to evaluate cell proliferation, inflammation infiltration, and reactive oxygen species (ROS) production, respectively. In vitro, 100 μg/mL and 200 μg/mL ADSC-EVs were used to treat photoaging fibroblasts (FBs). β-galactosidase staining and collagen 1 and matrix metalloproteinase 3 (MMP-3) expression were analyzed to evaluate FB senescence. To explain the protective mechanism of ADSC-EVs, their role in regulating ROS production, antioxidant enzyme expression, cell cycle arrest, and inflammation was evaluated. Results: In vivo, we showed that ADSC-EVs decreased skin wrinkles in mice with UVB-induced photoaging, while promoting epidermal cell proliferation and attenuating macrophage infiltration and ROS production. In vitro, we showed that ADSC-EVs increased FB activity and protected FBs from UVB-induced senescence, attenuated raw 264.7 cell differentiation from M0 to M1 macrophages, reduced intracellular ROS production, promoted antioxidant enzyme expression, and rescued FBs from cell cycle arrest. Conclusion: The anti-photoaging effect of ADSC-EVs was attributed to their ability to attenuate ROS production and the inflammatory response, which are key factors in MMP activation and collagen degradation.

show abstract

“…PA supplementation also improves white adipocyte function, boosts fatty acid oxidation, and mitigates hepatic steatosis in obese mice [ 16 , 18 – 20 ]. Thus, the current study, was aimed to investigate the potential therapeutic effects of 7-MEGA™, a purified form of omega-7 containing over 98.5% purity and more than 500 mg/g of PA [ 25 ], on both HFD mice and 3T3-L1 adipocytes. 7-MEGATM comprises various fatty acid esters beyond PA (Supplementary Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…AlaskOmega® Omega 7, also known as Omega‑7 fatty acid or 7‑MEGA™, is a highly concentrated palmitoleic acid (C16:1) [ 25 ]. 7-MEGA™ (purity 98.5% of omega-7, containing > 500 mg/g of palmitoleic acid (Fig.…”

Section: Methodsmentioning

confidence: 99%

7-MEGA™ inhibits adipogenesis in 3T3-L1 adipocytes and suppresses obesity in high-fat-diet-induced obese C57BL/6 mice

Won,

Bak,

Chandimali

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

Background Overweight, often known as obesity, is the abnormal and excessive accumulation of fat that exposes the health of a person at risk by increasing the likelihood that they may experience many chronic conditions. Consequently, obesity has become a global health threat, presenting serious health issues, and attracting a lot of attention in the healthcare profession and the scientific community. Method This study aims to explore the anti-adipogenic properties of 7-MEGA™ in an attempt to address obesity, using both in vitro and in vivo research. The effects of 7MEGA™ at three distinct concentrations were investigated in obese mice who were given a high-fat diet (HFD) and 3T3-L1 adipocytes. Results 7MEGA™ decreased the total fat mass, overall body weight, and the perirenal and subcutaneous white adipose tissue (PWAT and SWAT) contents in HFD mice. Additionally, 7MEGA™ showed promise in improving the metabolic health of individuals with obesity and regulate the levels of insulin hormone, pro-inflammatory cytokines and adipokines. Furthermore, Peroxisome proliferator-activated receptors (PPAR) α and γ, Uncoupling Protein 1 (UCP-1), Sterol Regulatory Element-Binding Protein 1 (SREBP-1), Fatty Acid-Binding Protein 4 (FABP4), Fatty Acid Synthase (FAS), Acetyl-CoA Carboxylase (ACC), Stearoyl-CoA Desaturase-1 (SCD-1) and CCAAT/Enhancer-Binding Protein (C/EBPα) were among the adipogenic regulators that 7MEGA™ could regulate. Conclusion In summary, this study uncovered that 7MEGA™ demonstrates anti-adipogenic and anti-obesity effects, suggesting its potential in combating obesity.

show abstract

7‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts

Cited by 4 publications

References 44 publications

Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study

Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study

Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation

7-MEGA™ inhibits adipogenesis in 3T3-L1 adipocytes and suppresses obesity in high-fat-diet-induced obese C57BL/6 mice

Contact Info

Product

Resources

About