7-methoxycoumarins from Micromelum minutum

Cytotoxic activity of coumarins fromMicromelum minutum

“…In Indochina, the roasted and crushed leaves are rubbed on to skin irritated by scabies and are also considered to be emmenagogues (Perry, 1980). The species is well known to contain coumarins, but depending on the collection location, the compounds isolated can also be different (Rahmani et al, 1994(Rahmani et al, , 2003Susidarti et al, 2006;Tantivatana et al, 1983;Das et al, 1984). The first sample collected in Peninsula Malaysia yielded micromelin and a new dihydrocinnamic acid derivative of micromelin, while another sample from a different location (also in Peninsular Malaysia) yielded tetracyclic microminutinin and 6-methoxymicrominutinin (Rahmani et al, 1994).…”

Phebaclavin I, a novel 3-prenylated coumarin, and trichoclin acetate, a new natural furocoumarin, from the aerial parts ofPhebaliumaff.tuberculosum(Rutaceae)

“…tuberculosum led to the isolation of twenty-five secondary metabolites, among which eight simple coumarins, identified as umbelliferone [12], isomeranzin [13], meranzin hydrate [14], murrangatin [15], murrangatin diacetate [16], murralongin [1], leptodactylone [17] and 5,7,8-trimethoxycoumarin [18], nine furocoumarins, identified as heraclenol [19], xanthotoxol [11], trichoclin [11], trichoclin acetate [11], imperatorin [20], isogosferol [21], 8-geranyloxypsoralen [22], (E, E )-8-(7-hydroxy-3,7-dimethylocta-2,5-dienyloxy)psoralen [8] and marmesin [23], two pyranocoumarins, xanthyletin [24] and (þ)-decursinol [25] and finally, six 3-prenylated coumarins, phebaclavin A, B, D, G, H, previously isolated from P. clavatum [2], and the new phebaclavin I (1).…”

C-7 oxygenated coumarins from the fruits of Micromelum minutum

“…The leaves are used traditionally as a febrifuge, the stems as a carminative, and the flowers and fruits as an expectorant and a purgative, respectively (Pongboonrod, 1958). The genus Micromelum species are known to contain 6-and 8-prenylated coumarins (Lamberton et al, 1967;Cassady et al, 1979;Das et al, 1984;Kamperdick et al, 1999;). Previous investigation of the leaves of M. minutum led to the isolation of bioactive coumarin derivatives such as microminutin (Tantivatana et al, 1983), flindersine, 7,8-dioxygenated coumarins, and triterpenes (Tantivatana et al, 1983;Tantishaiyakul et al, 1986;Rahmani et al, 2003;Susidarti et al, 2006), as well as a pyranoquinoline alkaloid (Tantivatana et al, 1983).…”