73 Study of lipid profile and thyroid hormones in patients with uterine fibroids

Peshkova, Tamar; Nakashidze, Irina; Petrovič, Nataša; Beridze, Sophio; Kedelidze, Nino; Artmeladze, Mikheil; Kamashidze, Koba

doi:10.1136/ijgc-2020-igcs.69

Cited by 3 publications

(4 citation statements)

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“…Nevertheless, prior studies have reported correlational associations between many of these diseases and plasma TG levels or risk factors correlated to plasma TGs. For example, studies had documented positive correlations between leiomyoma risk and plasma TG levels ( Uimari et al, 2016 ; Tonoyan et al, 2021 ; Peshkova et al, 2020 ). Others had shown diverticular disease risk is positively associated with BMI, body fat percentage, and visceral fat area ( Shih et al, 2022 ; Freckelton et al, 2018 ; Böhm, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits

Park

Bafna

Forrest

et al. 2023

eLife

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Background: Causality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems. Methods: Here, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2,600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p < 0.05) in an independent cohort from FinnGen. To account for potential horizontal pleiotropy and the influence of invalid instrumental variables, we performed sensitivity analyses using MR-Egger regression, weighted median estimator, and MR-PRESSO. Finally, we used multivariable MR controlling for correlated lipid fractions to distinguish the independent effect of plasma TG levels. Results: Our results identified 7 disease traits reaching Bonferroni-corrected significance in both the discovery (p < 1.92 × 10-5) and replication analyses (p < 2.26 × 10-4), suggesting a causal relationship between plasma TG levels and ASCVDs, including coronary artery disease (OR 1.33, 95% CI 1.24-1.43, p = 2.47 × 10-13). We also identified 12 disease traits that were Bonferroni-significant in the discovery or replication analysis and at least nominally significant in the other analysis (p < 0.05), identifying plasma TG levels as a novel potential risk factor for 9 non-ASCVD diseases, including uterine leiomyoma (OR 1.19, 95% CI 1.10-1.29, p = 1.17 × 10-5). Conclusions: Taking a phenome-wide, two-sample MR approach, we identified causal associations between plasma TG levels and 19 disease traits across organ systems. Our findings suggest unrealized drug repurposing opportunities or adverse effects related to approved and emerging TG-lowering agents, as well as mechanistic insights for future studies. Funding: RD is supported by the National Institute of General Medical Sciences of the National Institutes of Health (NIH) (R35-GM124836) and the National Heart, Lung, and Blood Institute of the NIH (R01-HL139865 and R01-HL155915).

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Section: Discussionmentioning

confidence: 99%

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits

Park

Bafna

Forrest

et al. 2023

eLife

View full text Add to dashboard Cite

show abstract

“…Prior studies had reported correlational associations between many of these diseases and plasma TG levels or risk factors correlated to plasma TGs. For example, studies had documented positive correlations between leiomyoma risk and plasma TG levels (Uimari et al, 2016) (Tonoyan et al, 2021) (Peshkova et al, 2020). Others had shown diverticular disease risk is positively associated with BMI, body fat percentage, and visceral fat area (Shih et al, 2022) (Freckelton et al, 2018) (Böhm, 2021).…”

Section: Discussionmentioning

confidence: 99%

Phenome-wide Mendelian randomization study of plasma triglycerides and 2,600 disease traits

Park

Bafna

Forrest

et al. 2022

Preprint

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BackgroundCausality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems.MethodsHere, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2,600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p < 0.05) in an independent cohort from FinnGen. To account for potential horizontal pleiotropy and the influence of invalid instrumental variables, we performed sensitivity analyses using MR-Egger regression, weighted median estimator, and MR-PRESSO. Finally, we used multivariable MR controlling for correlated lipid fractions to distinguish the independent effect of plasma TG levels.ResultsOur results identified 7 disease traits reaching Bonferroni-corrected significance in both the discovery (p < 1.92 × 10-5) and replication analyses (p < 2.26 × 10-4), supporting a causal relationship between plasma TG levels and ASCVDs, including coronary artery disease (OR 1.33, 95% CI 1.24-1.43, p = 2.47 × 10-13). We also identified 12 disease traits that were Bonferroni-significant in the discovery or replication analysis and at least nominally significant in the other analysis (p < 0.05), identifying plasma TG levels as a novel risk factor for 9 non-ASCVD diseases, including uterine leiomyoma (OR 1.19, 95% CI 1.10-1.29, p = 1.17 × 10-5).ConclusionsTaking a phenome-wide, two-sample MR approach, we identified causal associations between plasma TG levels and 19 disease traits across organ systems. Our findings suggest unrealized drug repurposing opportunities or adverse effects related to approved and emerging TG-lowering agents as well as mechanistic insights for future study.

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“…Breast Benign tumor (BBT) consider as a significant breast health problem within women of all ages. It is well known that hormones, in particular, steroids and non-steroids, have been associated with breast tumors [1] [2] [3]. Vitamin D is a steroid hormone known to influence multiple organ functions in our body, including the heart, the skeletal system, the lungs, the intestines and the mammary glands.…”

mentioning

confidence: 99%

“…The blood levels of fT3 and fT4, antibodies against thyroid peroxidase and the TSH receptor were significantly altered at the time of primary diagnosis of BBT [9]. Notably, the thyroid hormones alteration was also revealed within Uterine fibroids [1]. General hormonal changes may lead to increas the risk also numerous tumors, including breast benign tumors [2].…”

mentioning

confidence: 99%

Vitamin D and Thyroid Hormones in Patients With Breast Benign Tumor

Glonti¹,

Vadachkoria²,

Ungiadze³

2021

jecm

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The Breast Benign tumor (BBT) is currently considered a significant breast health problem within women of all ages. In the present study, we aimed to investigate the Tumor markers CA125 and CA153, thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and vitamin D within benign breast tumor (BBT) during the reproduction ages. Twenty patients (ten patients in the control group and ten patients in cases (Breast Benign Tumor); Notably, the studies confirm the decrease in FT4 and FT3 and increase of the thyroid-stimulating hormone (TSH). In addition, the decreased level of Vitamin D is also revealed in BBT.

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73 Study of lipid profile and thyroid hormones in patients with uterine fibroids

Cited by 3 publications

References 0 publications

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits

Phenome-wide Mendelian randomization study of plasma triglycerides and 2,600 disease traits

Vitamin D and Thyroid Hormones in Patients With Breast Benign Tumor

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