76‐year‐old Man With a Cerebellar Lesion

Richardson, Marlin Dustin; Somerset, Hilary; Kleinschmidt‐DeMasters, Bette K.; Waziri, Allen

doi:10.1111/j.1750-3639.2012.00638.x

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Only 4 cases of BCMM with brain metastasis have been reported to date (6)(7)(8)(9). In the current case, the cytological balloon cell change was associated with loss of HMB-45 expression.…”

Section: Discussionmentioning

confidence: 52%

Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change

Goto¹,

Shimauchi²,

Fukuchi³

et al. 2019

Acta Derm Venerol

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Wet wrap therapy, based on skin application of a double layer of tubular bandages or gauze with a moist first inner layer and a dry second outer layer, is utilized to treat various pruritic conditions, in particular severe and refractory atopic dermatitis. This review, by literature search, evaluates current knowledge about wet wrap therapy. Wet wrap therapy superimposed topical corticosteroids appears more efficient than emollients only, at least for short-time treatments. Despite higher efficacy, there is a tendency towards more frequent infections when topical corticosteroids are covered with wet wrap bandages compared to emollients only. While temporary suppression of hypothalamic-pituitary-adrenocortical-axis was seen due to systemic bioactivity of corticosteroids, no long-term observation studies on putative adverse effects were identified. One hypothesis suggests that wet wrap therapy may trigger increased lamellar body secretion resulting in recovery of the damaged intercellular lipid laminar structure. Otherwise, little investigation on mechanisms exists.

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“…Only 4 cases of BCMM with brain metastasis have been reported to date (6)(7)(8)(9). In the current case, the cytological balloon cell change was associated with loss of HMB-45 expression.…”

Section: Discussionmentioning

confidence: 52%

Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change

Goto¹,

Shimauchi²,

Fukuchi³

et al. 2019

Acta Derm Venerol

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“…Over the years, there have been different reports of BCM since Gardner’s first report in 1970 [ 9 ], which reported a case of BCM developed at the level of the back of an older patient. Since then, descriptions of this entity have multiplied [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , ...…”

Section: Discussionmentioning

confidence: 99%

“…We also remember entities such as clear-cell syringoma, granular cell tumor, malignant eccrine acrospiroma, sebaceous carcinoma, atypical fibroxanthoma and lepromatous leprosy. In all these cases, immunohistochemical investigations and essential integration with clinical-anamnestic information may help in the correct nosographic classification [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature

et al. 2022

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Background: balloon cell melanoma represents less than 1% of all histological forms of malignant melanoma and represents a diagnostic challenge for the dermatopathologist. Methods: in this paper we present our cases of BCM found in our daily practice from 1 January 2008 to 31 December 2021, and we conduct a review of the literature relating to this entity in the period from the first description, 1970, to early 2022. Results: four cases of melanoma balloon cell have been extrapolated from our electronic database, while in the review of the literature we have identified 115 cases of patients with primary and/or metastatic BCM. Conclusions: we believe that future studies with numerous case series are essential not only to increase the knowledge of the pathophysiology of this neoplasm but also to correctly evaluate the response of BCM patients to new oncological therapies.

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“…8,9,51,62 Compared to ocular lesions, recent reports of neurological BCM cases are available, all with brain metastases. 15,19,30,34,42 Respiratory, gastrointestinal, and gynecological lesions were the rarest primary presentations.…”

Section: Discussionmentioning

confidence: 99%

Balloon cell melanoma: a systematic review

et al. 2021

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Balloon cell melanoma (BCM) is a rare presentation of malignant melanoma characterized by large, foamy melanocytes lacking pigmentation. This is a comprehensive review of the clinical, dermoscopic, and histological features among BCM cases reported in the literature. A systematic review of all case reports and series published since 1970 was conducted via MEDLINE, Embase, and Web of Science, using "balloon cell melanoma" and synonymous search terms. Our systematic search identified 76 cases (49% male, 51% female) of BCM in the literature. The mean age at presentation was 57.81 years. Prior skin cancer, particularly melanoma (47%), accounted for 58% of pertinent medical history.Prominent clinical exam findings included raised (46%), ulcerated (73%) lesions larger than 1 cm (68%) in the lower extremities (35%). Median Breslow thickness of primary BCM cases was 2.5 mm. Hairpin vessels (75%) and structureless architecture (75%) were predominant on dermoscopy. Notable histopathology included large (47%), vacuolated (58%) cells with foamy cytoplasm (62%) and conspicuous nucleoli (27%). Positive S-100 immunohistochemistry (73%) was most frequently employed to diagnose BCM. We observed 47% primary and 53% metastatic BCM cases. Of metastatic BCMs, balloon cells in the primary lesion were unknown in 48%, devoid in 33%, and present in 20% of cases.All metastases displayed predominant balloon cell morphology. BCM may represent an advanced phase in the progression of malignant melanoma. Improved awareness of BCM characteristics among clinicians may reduce the risk of misdiagnoses.

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76‐year‐old Man With a Cerebellar Lesion

Cited by 4 publications

References 9 publications

Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change

Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change

Balloon Cell Melanoma: Presentation of Four Cases with a Comprehensive Review of the Literature

Balloon cell melanoma: a systematic review

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