7T CEST MRI: A potential imaging tool for the assessment of tumor grade and cell proliferation in breast cancer

Zaric, Olgica; Farr, Alex; Rodriguez, Esau Poblador; Mlynarik, Vladimir; Bogner, Wolfgang; Gruber, Stephan; Asseryanis, Ella; Singer, Christian F.; Trattnig, Siegfried

doi:10.1016/j.mri.2019.03.004

Cited by 31 publications

(43 citation statements)

References 36 publications

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“…Δω DS ≈ 0 ppm). In contrast to previously reported fat‐correction approaches, the proposed normalization neither requires a fat saturation, or water excitation scheme, nor requires additional measurements as e.g. in the case of a Dixon‐based water‐fat separation .…”

Section: Discussionmentioning

confidence: 99%

“…Applications range from tumor grading, over the assessment of therapy response after radiation treatment, to the differentiation of histologic and genetic subtypes of tumors . Although most applications aim at examination of brain tumors, there is also an emerging interest in the application of APT‐CEST MRI for the diagnosis of breast cancer …”

Section: Introductionmentioning

confidence: 99%

“…The problem of an incorrect normalization and the observation of the resulting pseudo‐CEST signals at the spectral positions of lipid resonances were first reported by Lu et al Moreover, a strong dependence of the Z ‐spectrum on the TE of the image readout was reported as a result of the varying phase relation of the water and fat signal . Recent studies of APT CEST in the human breast used fat suppression, water excitation, or a Dixon‐based water–fat separation to overcome fat signal–induced artifacts. However, all of these approaches require either additional RF power or further image acquisitions.…”

Section: Introductionmentioning

confidence: 99%

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A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging

Zimmermann

Korzowski

Breitling

et al. 2019

Magnetic Resonance in Med

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Purpose: The application of amide proton transfer (APT) CEST MRI for diagnosis of breast cancer is of emerging interest. However, APT imaging in the human breast is affected by the ubiquitous fat signal preventing a straightforward application of existing acquisition protocols. Although the spectral region of the APT signal does not coincide with fat resonances, the fat signal leads to an incorrect normalization of the Z-spectrum, and therefore to distorted APT effects. In this study, we propose a novel normalization for APT-CEST MRI that corrects for fat signal-induced artifacts in the postprocessing without the need for application of fat saturation schemes or water-fat separation approaches. Methods: The novel normalization uses the residual signal at the spectral position of the direct water saturation to estimate the fat contribution. A comprehensive theoretical description of the normalization for an arbitrary phase relation of the water and fat signal is provided. Functionality and applicability of the proposed normalization was demonstrated by in vitro and in vivo experiments. Results: In vitro, an underestimation of the conventional APT contrast of approximately −1.2% per 1% fat fraction was observed. The novel normalization yielded an APT contrast independent of the fat contribution, which was also independent of the | 921 ZIMMERMANN Et Al.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging

Zimmermann

Korzowski

Breitling

et al. 2019

Magnetic Resonance in Med

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“…In our study, increasing the power produced a larger CEST signal, which facilitated signal detection. Unfortunately, using a higher saturation power not only increases the magnetization transfer (MT) signal dramatically but also increases the likelihood of reaching specific absorption rate (SAR) safety limits [55, 56]. Therefore, a relatively lower saturation power may reduce the effects of MT and is preferred in a clinical setting with regard to safety concerns.…”

Section: Resultsmentioning

confidence: 99%

Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo

et al. 2019

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BackgroundNanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, the lack of a real-time visualization imaging technology to monitor drug distribution greatly limits its clinical application. Image-tracked drug delivery is of great clinical interest; it is useful for identifying those patients for whom the therapy is more likely to be beneficial. This paper discusses a novel nanomedicine that displays features of nanoparticles and facilitates functional magnetic resonance imaging but is challenging to prepare.ResultsTo achieve this goal, we synthesized an acylamino-containing amphiphilic block copolymer (polyethylene glycol-polyacrylamide-polyacetonitrile, PEG-b-P(AM-co-AN)) by reversible addition-fragmentation chain transfer (RAFT) polymerization. The PEG-b-P(AM-co-AN) has chemical exchange saturation transfer (CEST) effects, which enable the use of CEST imaging for monitoring nanocarrier accumulation and providing molecular information of pathological tissues. Based on PEG-b-P(AM-co-AN), a new nanomedicine PEG-PAM-PAN@DOX was constructed by nano-precipitation. The self-assembling nature of PEG-PAM-PAN@DOX made the synthesis effective, straightforward, and biocompatible. In vitro studies demonstrate decreased cytotoxicity of PEG-PAM-PAN@DOX compared to free doxorubicin (half-maximal inhibitory concentration (IC50), mean ~ 0.62 μg/mL vs. ~ 5 μg/mL), and the nanomedicine more efficiently entered the cytoplasm and nucleus of cancer cells to kill them. Further, in vivo animal experiments showed that the nanomedicine developed was not only effective against breast cancer, but also displayed an excellent sensitive CEST effect for monitoring drug accumulation (at about 0.5 ppm) in tumor areas. The CEST signal of post-injection 2 h was significantly higher than that of pre-injection (2.17 ± 0.88% vs. 0. 09 ± 0.75%, p < 0.01).ConclusionsThe nanomedicine with CEST imaging reflects the characterization of tumors and therapeutic functions has great potential medical applications.

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“…In terms of diagnosis and tumor detection, 7-Tesla MRI has been described as a safe procedure in breast cancer [51]. 3D chemicalexchange saturation transfer imaging (CEST) showed that magnetization transfer asymmetry values were positively correlated with tumor proliferation and that this index might become a biomarker of high interest in breast tumor characterization [52]. In prostate cancer, early detection of adenocarcinoma with discrimination among cancer stages has been reported as possible in mice model using apparent diffusion coefficient (ADC) [53].…”

Section: Discussionmentioning

confidence: 99%

Are We Heading to the Future of Musculoskeletal Tumor Imaging with Ultra-High Field 7T MRI?

Fouré¹,

Rochwerger²,

Troter³

et al. 2020

COR

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Background and objectives: Sarcoma preoperative planning critically depends on MRI, sometimes uninformative when compartments barriers or critical structures are involved. objective: to prospectively assess the feasibility and the potential of 7T MRI in sarcoma. Methods: Two patients with femoral chondrosarcoma were CT and MRI (1.5 and 7T) scanned with T1W, T2W, GRE and DTI sequences. Image quality and characteristics of the tumors were compared between these modalities. Results: In-plane resolution was higher at 7T as compared to 1.5T MRI, tumor delineation was more reliable and soft tissue involvement was clearer. DT imaging and corresponding ADC mapping allowed a clear distinction between edema and tumor and identified tumor involvement of collateral ligament allowing healthy structures sparing with histopathology confirmation. 7T MRI was also able to define cortical reaction as precisely as CT imaging. Conclusion: Musculoskeletal tumours UHF-MRI is promising. Higher resolution and enhanced signal to noise ratio improved tumoral assessment, infiltration and cortex changes. One could expect this nonradiating technique to replace CT investigation for bone tumours assessment and open new perspectives in the fields of vascular or nerve salvage and response to chemo/radiotherapy. Healthy tissue sparing might be facilitated with impacts on function, complication or reconstruction type.

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7T CEST MRI: A potential imaging tool for the assessment of tumor grade and cell proliferation in breast cancer

Cited by 31 publications

References 36 publications

A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging

A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging

Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo

Are We Heading to the Future of Musculoskeletal Tumor Imaging with Ultra-High Field 7T MRI?

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