8.17 Chromatographic Separations and Analysis: Chiral Gas Chromatography

Morrison, Calum

doi:10.1016/b978-0-08-095167-6.00834-x

“…A separate chapter should be dedicated to enantio-prep-GC that was reviewed by Schurig in 2012 [42]. Nevertheless, the diffusion of this approach was limited because of the low α value of the chiral selectors used as stationary phases (usually in the range 1.02-1.20) in most of the cases avoiding collection of enantiomeric pure components [43]. Different approaches were exploited in micropreparative separation of enantiomers using wide-bore columns coated with cyclodextrin stationary phases (CSPs) by Bicchi et al [44,45].…”

Section: Introductionmentioning

confidence: 99%

Evolution and status of preparative gas chromatography as a green sample-preparation technique

Mondello

¹

,

Pantò

²

,

Ragonese

³

et al. 2015

TrAC Trends in Analytical Chemistry

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A Traceless Chiral Shift Reagent Based on Nonbonding Interactions with Single‐Handed Helical Poly(quinoxaline‐2,3‐diyl)

Fujie

¹

,

Yamamoto

²

,

Suginome

³

2023

Angewandte Chemie

2

0

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A single-handed poly(quinoxaline-2,3-diyl) (PQX) has been found to serve as a new type of chiral shift reagent (CSR) for determining the enantiomeric ratio by NMR spectroscopy. Even though there is no specific binding site in the PQX, its nonbonding interaction with chiral analytes leads to a significant shift of the NMR chemical shift, allowing quantification of the enantiomeric ratio. The new type of CSR has the advantages of a wide scope of analytes including ethers, haloalkanes, and alkanes, easy tunability of the degree of chemical shifts by measurement temperature, and erasability of proton signals of CSR because of the short spin-spin (T 2 ) relaxation of the macromolecular scaffold.

show abstract

A Traceless Chiral Shift Reagent Based on Nonbonding Interactions with Single‐Handed Helical Poly(quinoxaline‐2,3‐diyl)

Fujie

¹

,

Yamamoto

²

,

Suginome

³

2023

View full text Add to dashboard Cite

A single-handed poly(quinoxaline-2,3-diyl) (PQX) has been found to serve as a new type of chiral shift reagent (CSR) for determining the enantiomeric ratio by NMR spectroscopy. Even though there is no specific binding site in the PQX, its nonbonding interaction with chiral analytes leads to a significant shift of the NMR chemical shift, allowing quantification of the enantiomeric ratio. The new type of CSR has the advantages of a wide scope of analytes including ethers, haloalkanes, and alkanes, easy tunability of the degree of chemical shifts by measurement temperature, and erasability of proton signals of CSR because of the short spin-spin (T 2 ) relaxation of the macromolecular scaffold.

show abstract

8.17 Chromatographic Separations and Analysis: Chiral Gas Chromatography

Cited by 4 publications

References 76 publications

Evolution and status of preparative gas chromatography as a green sample-preparation technique

Evolution and status of preparative gas chromatography as a green sample-preparation technique

A Traceless Chiral Shift Reagent Based on Nonbonding Interactions with Single‐Handed Helical Poly(quinoxaline‐2,3‐diyl)

A Traceless Chiral Shift Reagent Based on Nonbonding Interactions with Single‐Handed Helical Poly(quinoxaline‐2,3‐diyl)

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