8 A multi-institutional outcome and prognostic factor analysis of radiosurgery (RS) for resectable single brain metastasis

Auchter, Richard M.; Lamond, John P.; Alexander, Eben; Buatti, John M.; Chappell, Rick; Friedman, William A.; Kinsella, T.; Levin, Allan B.; Noyes, William; Schultz, Chris; Loeffler, J.S.; Mehta, M.P.

doi:10.1016/0360-3016(95)97673-o

Cited by 25 publications

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“…4 prognostic factors elicited from this study are classical survival determinants reported to be shared in common by all NSCLC whatever the metastatic site (Zimm et al, 1981;DienerWest et al, 1989;Komarnicky et al, 1991;Lonjon et al, 1994;Ryan et al, 1995;Ando et al, 1996;Auchter et al, 1996;Gaspar et al, 1997;Hsiung et al, 1998;Agboola et al, 1998;Lagerwaard et al, 1999), or by brain metastases whatever the primary tumour (Zimm et al, 1981;Diener-West et al, 1989;Komarnicky et al, 1991;Lonjon et al, 1994;Auchter et al, 1996;Gaspar et al, 1997;Agboola et al, 1998;Lagerwaard et al, 1999). These factors are gender, performance status, age and serum sodium level.…”

Section: Discussionmentioning

confidence: 71%

Brain metastases at the time of presentation of non-small cell lung cancer: a multi-centric AERIO* analysis of prognostic factors

et al. 2001

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Patients with lung cancer frequently suffer from brain metastases at the time of presentation. This condition affects approximately 10% of non-small cell lung cancer (NSCLC) patients (Newman and Hansen, 1974;Sorensen et al, 1988). Surgery is feasible only for a small proportion of these patients. Whole brain radiotherapy has been, hitherto, the generally recommended treatment in inoperable patients. The survival of NSCLC patients with brain metastases is poor, reported to be between 3 to 6 months in patients treated with medical therapies, either radiotherapy or chemotherapy (compared to 6-10 months in other advanced NSCLC (Paesmans et al, 1995;Shepherd, 1999)). Furthermore, brain metastases at the time of presentation of lung cancer seems to be a worse prognosis (Sorensen et al, 1988) than metachronous brain metastases.New therapeutic strategies are needed to improve the outcome of these patients. The knowledge of prognostic determinants might be important in both clinical trials and routine practice (Komaki et al, 1993;Charloux et al, 1997;Paesmans et al, 1997;Merrill et al, 1999). In the former setting, prognostic co-variables must be taken into account in survival analyses; by way of illustration, in a given randomized trial, the statement that a difference in survival is related to the effects of the treatment must be supported by a proportional hazards model demonstrating that this effect does not depend on well-known prognostic determinants (Depierre et al, 1999;Furuse et al, 1999). In the second setting, a therapeutic decision might be influenced by the state of prognostic variables (Komaki et al, 1993).Here we especially take a look at the prognostic significance of 2 specific serum markers, CYFRA 21-1 and neuron-specific enolase (NSE). The prognostic value of CYFRA 21-1 (a fragment of cytokeratin subunit 19) in this disease has been suggested (Pujol et al, 1993;Wieskopf et al, 1995;Brechot et al, 1997). NSE, the γ-subunit of enolase, has been widely investigated as a marker of small cell lung cancer (SCLC;Jorgensen et al, 1989). Although only a small proportion of NSCLC presented with a high NSE level, this marker might indirectly reflect; i) a neuroendocrine component of the disease in favour of tumour heterogeneity; ii) a Summary A multi-centre retrospective study involving 4 French university institutions has been conducted in order to identify routine pretherapeutic prognostic factors of survival in patients with previously untreated non-small cell lung cancer and brain metastases at the time of presentation. A total of 231 patients were recorded regarding their clinical, radiological and biological characteristics at presentation. The accrual period was January 1991 to December 1998. Prognosis was analysed using both univariate and multivariate (Cox model) statistics. The median survival of the whole population was 28 weeks. Univariate analysis (log-rank), showed that patients affected by one of the following characteristics proved to have a shorter survival in comparison with the opposite status...

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Section: Discussionmentioning

confidence: 71%

Brain metastases at the time of presentation of non-small cell lung cancer: a multi-centric AERIO* analysis of prognostic factors

et al. 2001

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“…Studies are conflicting regarding the use of SRS in groups of brain metastasis patients with differing primaries. Bindal et al 21 noted a significant survival benefit for patients treated with surgical resection compared with SRS, while Auchter et al 22 concluded that SRS was as efficacious as resection. In yet a third study, Muacevic et al 23 found no marked difference in survival.…”

Section: Discussionmentioning

confidence: 99%

Use of the Radiation Therapy Oncology Group recursive partitioning analysis classification system and predictors of survival in 19 women with brain metastases from ovarian carcinoma

Chen¹,

Lee²,

Barnett³

et al. 2005

Cancer

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“…Stereotactic radiosurgery (SRS) often is administered to patients who have a good performance status and 3 metastases of suitable size (4 cm). 7,8 SRS is administered in a single fraction and has some potential benefits compared with conventional radiotherapy like WBRT. SRS is more precise, requires less treatment time, and reduces the volume of surrounding normal brain tissue being irradiated.…”

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Stereotactic radiosurgery alone versus resection plus whole‐brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients

Rades

Bohlen

Pluemer³

et al. 2007

Cancer

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This article reports an experimental and theoretical study of the peroxide‐induced degradation of polypropylene in a corotating twin‐screw extruder. Experiments were performed with different peroxide concentrations and different operating conditions. The evolution of the chemical reaction along the extruder was monitored with specific sampling devices. Material changes were characterized by rheological measurements and via the determination of the molecular weights of samples collected at the same locations. The theoretical results were obtained with a model that coupled the interactions between flow conditions encountered in the extruder, the kinetics of the reaction, and the changes in the viscosity induced by changes in the molecular weight. The experimental results evidenced the relationships between the process conditions (peroxide concentration and processing parameters) and material properties (rheological properties and molecular structure of the modified polypropylene). Good agreement between the theoretical and experimental results was obtained. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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8 A multi-institutional outcome and prognostic factor analysis of radiosurgery (RS) for resectable single brain metastasis

Cited by 25 publications

References 0 publications

Brain metastases at the time of presentation of non-small cell lung cancer: a multi-centric AERIO* analysis of prognostic factors

Brain metastases at the time of presentation of non-small cell lung cancer: a multi-centric AERIO* analysis of prognostic factors

Use of the Radiation Therapy Oncology Group recursive partitioning analysis classification system and predictors of survival in 19 women with brain metastases from ovarian carcinoma

Stereotactic radiosurgery alone versus resection plus whole‐brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients

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