815 Calcium Antagonists-Induced Lower Urinary Tract Symptoms in Medical Patients

Elhebir, Elsamaul S.; Hughes, James L.; Hilmi, S.

doi:10.1016/s1569-9056(11)60802-6

Cited by 4 publications

(15 citation statements)

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“…A review article 6 identified five studies [7][8][9][10][11] investigating the relationship between CCB and storage LUTS. However, the results of this review were inconclusive: three studies demonstrated a link between CCB and LUTS/ nocturia; one study found no significant link; and one study reported an inverse relationship between CCB use and nocturia.…”

mentioning

confidence: 99%

Dihydropyridine calcium channel blockers and obstructive sleep apnea: Two underrecognized causes of nocturia?

Santiapillai

Tadtayev

Miles

et al. 2020

Neurourology and Urodynamics

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mentioning

confidence: 99%

Dihydropyridine calcium channel blockers and obstructive sleep apnea: Two underrecognized causes of nocturia?

Santiapillai

Tadtayev

Miles

et al. 2020

Neurourology and Urodynamics

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“…After the detailed evaluation of fifteen articles, 5 studies were included in the final review. Among the 10 excluded studies, 3 had no outcome of interest, 4 evaluated the association of urinary symptoms with other medications, one study reported the prevalence of commonly prescribed medications potentially contributing to urinary symptoms among geriatrics seeking care for incontinence, one study was published from Elhebir dissertation [ 16 ], and one dissertation from which the manuscripts of Hughes et al was published [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…All the studies were published in the last eight years (oldest in 2009 and latest in 2013). Of the five included studies, two were conducted in Australia [ 15 , 16 ] whereas the rest of the studies were conducted in the USA [ 17 ], Japan [ 18 ], and Netherlands [ 19 ]. The number of study population ranged from 38 to 3790, with majority of the studies (3/5) involving only males [ 15 , 18 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…The number of study population ranged from 38 to 3790, with majority of the studies (3/5) involving only males [ 15 , 18 , 19 ]. Three out of five studies were undertaken on individuals aged >40 years [ 15 , 16 , 19 ], whereas one study [ 17 ] included individuals ranging from 30 to 79 years of age and one study did not specify the criterion of age [ 18 ]. International prostate symptom score was the predominantly used research tool to assess the frequency and severity of LUTS [ 15 , 16 , 18 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three out of five studies were undertaken on individuals aged >40 years [ 15 , 16 , 19 ], whereas one study [ 17 ] included individuals ranging from 30 to 79 years of age and one study did not specify the criterion of age [ 18 ]. International prostate symptom score was the predominantly used research tool to assess the frequency and severity of LUTS [ 15 , 16 , 18 , 19 ]. Only one study used the American Urological Association-Symptom Index for the evaluation of LUTS [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Calcium Channel Blockers on Lower Urinary Tract Symptoms: A Systematic Review

Salman

Khan

Sulaiman

et al. 2017

BioMed Research International

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Background Numerous medications are known to be associated with the development of lower urinary tract symptoms (LUTS). One such medication group is calcium channel blockers (CCB). Objective To critically examine the literature regarding the involvement of CCB in manifestation of LUTS in humans. Methods A systematic literature search was conducted on PubMed, SciELO, Scopus, and OpenGrey databases to find all potentially relevant research studies before August 2016. Results Five studies met the inclusion criteria and were included in this review. Three out of five studies stated that CCB were involved in either precipitation or exacerbation of LUTS. As for the remaining two studies, one study found out that only the monotherapy of CCB was associated with increased prevalence of nocturia and voiding symptoms in young females, whereas the other study reported an inverse association of CCB with LUTS. The methodological quality of studies was considered high for four studies and low for one study. Conclusion Healthcare providers should make efforts for an earlier identification of the individuals at risk of LUTS prior to the commencement of CCB therapy. Moreover, patients should be counselled to notify their healthcare provider if they notice urinary symptoms after the initiation of CCB.

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Association between nocturnal polyuria and 24‐h blood pressure fluctuations in males with lower urinary tract symptoms: A multicenter prospective study

Kato,

Akaihata,

Takezawa

et al. 2023

Int J of Urology

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ObjectivesNocturnal polyuria (NP) is one of the causes of nocturia that impairs quality of life. It is necessary to consider that NP is latent when the initial treatment for nocturia is unsatisfactory. Therefore, it is important to establish a treatment for NP based on the pathophysiology. We have previously reported the relationship between NP and fluctuation in blood pressure. The present study aimed to investigate the association between NP and 24‐h blood pressure fluctuations in a multicenter prospective study.MethodsThis study included male patients with lower urinary tract symptoms. We categorized the patients into the nonnocturnal polyuria (non‐NP) group (≤0.33) and the NP group (>0.33) based on the nocturnal polyuria index from the frequency volume chart. We measured the 24‐h diurnal blood pressure and compared the two groups.ResultsAmong 90 patients, 46 in the non‐NP group and 44 in the NP group were included. There was no significant difference in the systolic and diastolic blood pressure during waking time between the two groups; however, the degree of systolic blood pressure reduction during sleep time in the NP group was significantly less than that in the non‐NP group (p = 0.039). In the multivariate analysis, systolic BP during sleep was significantly associated with NP (OR 0.970, p = 0.028).ConclusionNP is associated with inadequate nocturnal blood pressure reduction in males, suggesting that reduction in nocturnal blood pressure may lead to improvement in nocturia.

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815 Calcium Antagonists-Induced Lower Urinary Tract Symptoms in Medical Patients

Cited by 4 publications

References 0 publications

Dihydropyridine calcium channel blockers and obstructive sleep apnea: Two underrecognized causes of nocturia?

Dihydropyridine calcium channel blockers and obstructive sleep apnea: Two underrecognized causes of nocturia?

Effect of Calcium Channel Blockers on Lower Urinary Tract Symptoms: A Systematic Review

Association between nocturnal polyuria and 24‐h blood pressure fluctuations in males with lower urinary tract symptoms: A multicenter prospective study

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