86: Functional and anatomical integrity of spinal cord after in-utero spina bifida repair using cryopreserved human umbilical cord (HUC) Patch vs. Conventional repair (CR) in a Sheep Model

Abstract

and 25 mm (3.0% vs 1.2%, p<0.001). CL was overall more predictive of PTB in AA women (AUC 0.659 vs 0.629, p¼0.045) ( Figure 1). CL 20 mm was more sensitive but slightly less specific for predicting spontaneous PTB in AA women (sensitivity 11.9% vs 5.1%, p<0.001, specificity 99.0% vs 99.7%, p<0.001). At each measure of CL from 20 to 25 mm, CL was more predictive of spontaneous PTB in AA vs non-AA women. The rate of PTB was higher in AA women at each cutoff; AA women with CL 24 mm had a PTB rate similar to non-AA women with a CL 20 mm (48.5% vs 48.5%) ( Figure 2). CONCLUSION: CL is more predictive of spontaneous PTB in AA than in non-AA women. Spontaneous PTB rates are similar in AA women with CL 24 mm and non-AA women with CL 20 mm. These data suggest that the definition of short CL should be race-based given the difference in PTB risk. Future studies should test the efficacy of interventions at a longer CL threshold in AA women.86 Functional and anatomical integrity of spinal cord after in-utero spina bifida repair using cryopreserved human umbilical cord (HUC) Patch vs. Conventional repair (CR) in a Sheep Model