875P Performance and diagnostic accuracy of human papillomavirus testing on urine and self-collected vaginal samples in a referral population

Cho, H-W.; Lee, J.K.; Hong, Ji Hong

doi:10.1016/j.annonc.2020.08.1014

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another recent Korean study aimed to evaluate the diagnostic accuracy of two PCR-based hrHPV assays (Realtime HR-S and Anyplex II) on self-collected vaginal and urine samples for the detection of cervical precancer in a colposcopy population. In this study, Cho et al conclude that despite the comparable detection performance for hrHPV and CIN2+ on self-collected vaginal samples and clinician-collected cervical samples, the performance of these two particular hrHPV tests using urine was inferior to those using clinician-collected cervical samples in terms of detecting hrHPV and CIN2+ ( Table 2 ) [ 42 ]. In the most recent study, Cadman et al compared the performance of four vaginal self-sampling devices, including wet and dry transport methods between themselves and an initial stream urine sample using the Becton Dickinson Onclarity assay in 600 women referred for colposcopy.…”

Section: Recent Developments Of Urine Hpv Testingmentioning

confidence: 95%

Urine HPV in the Context of Genital and Cervical Cancer Screening—An Update of Current Literature

Daponte¹,

Michail

Daponte³

et al. 2021

Cancers

View full text Add to dashboard Cite

Within the previous decades, following the widespread implementation of HPV-related biomarkers and computerization in liquid-based cytology, screening for lower genital tract malignancies has been optimized in several parts of the world. Many organized anogenital cancer prevention systems have reached a point at which efficacy is more a matter of population coverage and less of available infrastructures. Meanwhile, self-sampling modalities in which biologic material (vaginal secretions, urine, etc.) is obtained by the individual and not the clinician and subsequently undergoes examination for HPV biomarkers enjoy appreciating acceptance. Bygone the initial skepticism that vaginal or urine HPV represents “passenger” transient infections, extensive scientific work has been conducted to optimize high-risk HPV (hrHPV) detection from this “novel” biologic material. Nowadays, several state-of-the-art meta-analyses have illustrated that self-sampling techniques involving urine self-sampling represent a feasible alternative strategy with potentially enhanced population coverage possessing excellent performance and sensitivity. Recently published scientific work focusing on urine HPV was reviewed, and after a critical appraisal, the following points should be considered in the clinical application of hrHPV urine measurements; (i) use of first-void urine (FVU) and purpose-designed collection devices; (ii) using a preservation medium to avoid human/HPV DNA degradation during extraction and storage; (iii) using polymerase chain reaction (PCR) based assays, ideally with genotyping capabilities; (iv) processing of a sufficient volume of whole urine; and (v) the use of an analytically sensitive HPV test/recovery of cell-free HPV DNA in addition to cell-associated DNA.

show abstract

Section: Recent Developments Of Urine Hpv Testingmentioning

confidence: 95%