90 Y microspheres prepared by sol-gel method, promising medical material for radioembolization of liver malignancies

Łada, W.; Iller, E.; Wawszczak, D.; Konior, Marcin; Dziel, Tomasz

doi:10.1016/j.msec.2016.05.050

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…At the end of this process, sort particles again to select the right product for use 10 . This product contains an amount of Y-89 in the components and was gone through a neutron irradiation in Da Lat nuclear reactor with the following irradiation parameters: Thermal neutron flux (2.3×10 13 n/cm 2 /s); Sample weight (1 g); Irradiation duration (180 h); Cooling duration (24 h). After irradiation, Y-90 glass microspheres were obtained and dissolved in 5 mL of NaCl 0.9% for further studies.…”

Section: Preparation Of Y-90 Glass Microspheresmentioning

confidence: 99%

“…Then, put the precipitate into a beaker and dissolve it with distilled water twice, stir until the solution formed a paste. Add 2 g of ascorbic acid to above mixture, stir for 30 min at 50 o C to form a bright yellow complex (Y-ascorbic-H2O-NH+4) 13 .…”

Section: Preparation Of Y-90 Gel Microspheresmentioning

confidence: 99%

“…Gel formation: Put 100 mL of 2-ethylhexanol-1 solution into a beaker containing the complex (Y-ascorbic-H 2 O-NH+ 4 ), add 2% of Span-80 solution and 2 mL of Octadecylamine solution (Octadecylamine soluble in petroleum at a ratio of 1:1), stir for 30 min at room temperature to form a gel precipitate. Then, wash the gel precipitate three times with C 2 H 5 OH solution 13 .…”

Section: Preparation Of Y-90 Gel Microspheresmentioning

confidence: 99%

“…Let the precipitate dry at room temperature for 48 h then have it dried at 200 o C for 4 h at a speed of 1 o C/min, next heat it at 400 o C for 2 h and heat at 650 o C for 2 h at a speed of 2 o C/minute. Finally, put the final product through a sieve with diameter of 63 µm 13 . At the end of this process, sort particles again to select the right product for use.…”

Section: Preparation Of Y-90 Gel Microspheresmentioning

confidence: 99%

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Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

Minh¹,

Dong²,

Thuan³

et al. 2020

Orient. J. Chem

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In this article, Y-90 microspheres are synthesized in three forms (resin microspheres, glass microspheres and gel microspheres) in Da Lat Nuclear Reactor (Vietnam) with a capacity of 500 kW for application in treatment of primary and secondary liver cancers. Characterization and quality of Y-90 microspheres are checked by field emission scanning electron microscopy (FE-SEM), energydispersive X-ray spectroscopy (EDX), chemical purity, radionuclide purity, radiochemical purity, sterility, bacterial endotoxins, toxic heavy metals (ICP-MS) and product stability over time. The results showed that Y-90 resin microspheres, Y-90 glass microspheres and Y-90 gel microspheres with particle sizes of 20-30 µm have a high specific activity to meet the quality standards of radiopharmaceuticals according to British Pharmacopoeia 2016. This is a promising radiopharmaceuticals in treatment of primary and secondary liver cancers using radioembolization in Vietnam.

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Section: Preparation Of Y-90 Glass Microspheresmentioning

confidence: 99%

Section: Preparation Of Y-90 Gel Microspheresmentioning

confidence: 99%

Section: Preparation Of Y-90 Gel Microspheresmentioning

confidence: 99%

Section: Preparation Of Y-90 Gel Microspheresmentioning

confidence: 99%

See 2 more Smart Citations

Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

Minh¹,

Dong²,

Thuan³

et al. 2020

Orient. J. Chem

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show abstract

“…The final product 90 Y microsphere has a specific activity suitable for hepatic malignant tumor transarterial embolization. [ 24 ] Besides, scientists invented theranostic barcoded nanoscale microparticles for personalized cancer medicine, which may be a boon for cancer patients. Yaari et al.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Zhang

Wang

et al. 2020

Macro Materials & Eng

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Microspheres applied in medical applications experience explosive development in recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both in economy and technology lay that cannot be ignored. For instance, microsphere technology has not been used in cell culture widely because of its uneconomical cost; as the core of drug‐loaded microsphere, targeted microsphere technology is still not mature enough. Besides, the common microsphere fabrication methods: microfluidic or emulsion technology is difficult to guarantee high biocompatibility of microsphere due to utilization of photoinitiator, crosslinking agent, surfactant, and other substances. Therefore, gas‐shearing technology has been proposed to solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than on single microspheres which begins with a minute introduction of microsphere preparation methods: microfluidic, coaxial electrospray, emulsion, and gas‐shearing technology. Then its medical applications: drug release, cell culture, bone tissue engineering, and hemostasis are discussed in detail. The disadvantages of fabrication methods and bottlenecks for medical applications at present are also stated. At the end, perspectives of microsphere development are put forward.

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Design synthesis of Y-90 glass microspheres and study of their therapeutic effects on mouse liver cancer cell line Hep3B

et al. 2022

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90 Y microspheres prepared by sol-gel method, promising medical material for radioembolization of liver malignancies

Cited by 8 publications

References 13 publications

Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Design synthesis of Y-90 glass microspheres and study of their therapeutic effects on mouse liver cancer cell line Hep3B

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