90dB Sensitivity in a Chip-Scale Swept-Source Optical Coherence Tomography System

Eggleston, Michael S.; Pardo, F.; Bolle, C.; Farah, Bob; Fontaine, Nicolas K.; Safar, H.; Cappuzzo, M.; Pollock, Corey; Bishop, David J.; Earnshaw, Mark

doi:10.1364/cleo_at.2018.jth5c.8

Cited by 19 publications

(14 citation statements)

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“…Upon implementation in OCT setups, these works reported up to a 91 dB sensitivity (26 mW on the sample 20 ) and a 13 µm axial resolution 16 . Further integration of OCT components was shown by Schneider et al 18 , who additionally integrated photodiodes, achieving a 64 dB sensitivity; Eggleston et al 21 presented an integrated interferometer, integrated balanced photodiodes, and a co-packaged MEMS mirror and measured sensitivity of 90 dB for skin imaging. Sancho-Dura et al 22 developed a handheld, tabletlike packaged, battery-driven OCT system for skin imaging, including an epiluminescence microscope and a clinical image camera with a total weight of 3 kg.…”

Section: Introductionmentioning

confidence: 99%

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

et al. 2021

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In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

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Section: Introductionmentioning

confidence: 99%

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

et al. 2021

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“…We envision our methodology to be suitable for such an application, wherein biocompatible micron-scale sensors that sense the local changes in the wound biochemistry can be freely distributed within the wound, followed by remote noncontact monitoring in 3D over time using OCT. Moreover, recent efforts to miniaturize the OCT system from benchtop to chip-scale 33 further empowers our approach, with broader implications to improve future healthcare monitoring in the clinic, at the home and on-the-go. (which was not certified by peer review) is the author/funder.…”

Section: Discussionmentioning

confidence: 99%

“…A-scans) can be acquired at rates exceeding 100kHz, allowing for volumetric imaging of roughly 3mm x 3mm x 3mm volumes per second with 10µm resolution in all dimensions. Recent work to miniaturize these systems 33,34 offers the potential of a portable, low-cost device for continuous in vivo monitoring, making SS-OCT an ideal candidate to acquire a non-invasive readout of microparticle biosensors.…”

Section: Design and Implementation Of Oct For Spatiotemporal Biosensingmentioning

confidence: 99%

Microparticle-based Biochemical Sensing Using Optical Coherence Tomography and Deep Learning

Shah

Zheng

et al. 2020

Preprint

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Advancing continuous health monitoring beyond vital signs to biochemistry will revolutionize personalized medicine. Herein, we report a novel platform to achieve remote biochemical monitoring using microparticle-based biosensors and optical coherence tomography (OCT). Stimuli-responsive, polymeric microparticles were designed to serve as freely-dispersible biorecognition units, wherein binding with a target biochemical induces volumetric changes of the microparticle. Analytical approaches to detect these sub-micron changes in 3D using OCT were devised by modeling the microparticle as an optical cavity, enabling estimations far below the resolution of the OCT system. As a proof of concept, we demonstrated the 3D spatiotemporal monitoring of glucose-responsive microparticles distributed throughout a tissue-mimic in response to dynamically-fluctuating levels of glucose. Deep learning was further implemented using 3D convolutional neural networks to automate the vast processing of the continuous stream of three-dimensional time series data, resulting in a robust end-to-end pipeline with immense potential for continuous in vivo biochemical monitoring.

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“…Demonstrations of (partly) miniaturized OCT systems in research have been accomplished in ophthalmic care using handheld probes, 330,[334][335][336][337][338][339][340][341][342][343] off-the-shelf micro-optical components 52,334,344 or PICs 329,345,346 for dermatologic care using handheld probes, [347][348][349][350][351][352][353] compact packaging of offthe-shelf components, 354 PICs, 353,[355][356][357] and handheld probes for oral 358 and for inner ear [359][360][361][362] imaging. The usage of off-the-shelf microcomponents seems to be the most mature technique for miniaturized OCT at the moment.…”

Section: Oct and Deep Learning Neural Network And Artificial Intelligencementioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

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Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

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90dB Sensitivity in a Chip-Scale Swept-Source Optical Coherence Tomography System

Cited by 19 publications

References 0 publications

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

Microparticle-based Biochemical Sensing Using Optical Coherence Tomography and Deep Learning

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

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