2008
DOI: 10.1016/s0168-8278(08)60912-5
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910 Electron Microscopic Findings in Non-Alcoholic Fatty Liver Disease; Is There Any Difference Between Hepatosteatosis and Steatohepatitis?

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“…NASH is characterized by hepatocyte injury, inflammation and fibrosis, which can lead to cirrhosis. Recent evidence suggests that simple steatosis may also have the potential to progress to fibrosis and cirrhosis-like NASH (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…NASH is characterized by hepatocyte injury, inflammation and fibrosis, which can lead to cirrhosis. Recent evidence suggests that simple steatosis may also have the potential to progress to fibrosis and cirrhosis-like NASH (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, it is reasonable to expect that the endothelial function is more deteriorated in NASH than in NAFL, but one recent electron microscopic investigation showed mitochondrial dysfunction in the two NAFLD groups, and the mitochondrial dysfunction, an important determinant of oxidative stress, was not statistically different in NAFL and NASH groups (40). However, the former finding is unreliable due to the insufficient size of the study group.…”
Section: Discussionmentioning
confidence: 99%