945 Cell Death Results From Digested Formula but Not Digested Fresh Human Breast: A Possible Mechanism for Necrotizing Enterocolitis

Penn, Alexander H.; Altshuler, Angelina E.; Small, James W.; Taylor, Seth R.; Dobkins, Karen R.; Schmid‐Schönbein, Geert W.

doi:10.1016/s0016-5085(12)60613-1

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“…Nondigested nutrients from formula reach the colon, where they can serve as substrates in bacterial fermentation. A high concentration of small organic acids has been shown to be cytotoxic and cause epithelial cell death in an in vitro model (30). Increased histopathology score and higher relative weight for the colon are indicative of inflammation and edema associated with IF feeding, relative to HM and BC.…”

Section: R9 Human Milk Bovine Colostrum and Necrotizing Enterocolitismentioning

confidence: 99%

Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

Jensen

Sangild

Lykke

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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BB, Thymann T. Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. Am J Physiol Regul Integr Comp Physiol 305: R4 -R12, 2013. First published May 8, 2013 doi:10.1152/ajpregu.00094.2013.-Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) and human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC protection in preterm piglets relative to IF. We hypothesized that HM exerts similar effects and that this effect is partly species-independent. Preterm piglets (n ϭ 40) received 2 days of total parenteral nutrition, followed by a rapid transition to full enteral feeding (15 ml·kg Ϫ1 ·2 h Ϫ1 ) for 2 days using BC (n ϭ 13), HM (n ϭ 13), or IF (n ϭ 14). Intestinal passage time and hexose absorption were tested in vivo. Body and organ weights were recorded on day 5, and macroscopic NEC lesions in the gastrointestinal tract were assessed. Intestinal samples were collected for determination of histomorphology, histopathology, tissue IL-6 and IL-8, organic acids, bacterial adherence by fluorescence in situ hybridization score, and digestive enzyme activities. Relative to IF, pigs from BC and HM showed longer intestinal passage time; higher weight gain, hexose absorptive capacity, mucosal proportion, and enzyme activities; lower NEC incidence, organic acid concentration, and IL-8 concentration; and reduced histopathology lesions. Tissue IL-6 concentration and bacterial adherence score were lower for HM, relative to both BC and IF groups. We conclude that BC and HM are both superior to IF in stimulating gut structure, function, and NEC resistance in preterm piglets.

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Section: R9 Human Milk Bovine Colostrum and Necrotizing Enterocolitismentioning

confidence: 99%

Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

Jensen

Sangild

Lykke

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

945 Cell Death Results From Digested Formula but Not Digested Fresh Human Breast: A Possible Mechanism for Necrotizing Enterocolitis

Cited by 1 publication

References 1 publication

Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

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