99mTc-LABELLED HEXAMETHYLPROPYLENEAMINE OXIME PHOTON EMISSION SCANS IN EPILEPSY

Biersack, H. J.; Reichmann, K.; Winkler, Christian; Stefan, Hermann; Bülau, P.; Kuhnen, K.; Penin, H.; Tyrrell, D. A. J.; Neirinckx, R.D.; Grüner, Katrin

doi:10.1016/s0140-6736(85)92612-1

Cited by 19 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Findings from PET studies are being translated into SPECT (Wagner, 1986), initially with iodine-123 compounds and, more recently, with technetium-99m agents such as exametazime. These have been demonstrated in a number of studies where the SPECT findings have been analogous to those found with PET, for example in epilepsy (Holman et a!, 1982;Biersak et a!, 1985;Podreka et a!, 1987), dementia (Cohen et a!, 1986;Sharp et a!, 1986), cerebral infarction (Holman et a!, 1982;Podreka et a!, 1987), and psychiatric and extrapyramidal disorders (Podreka et a!, 1987). However, as the principal agents used for many of the PET studies, fluorine-l8 deoxyglucose is an index of metabolic activity and technetium-99m exametazime is an indication of perfusion, and absolute comparisons are not strictly compatible physiologically.…”

Section: Discussionmentioning

confidence: 99%

Single-Photon Emission Computerised Tomography (Spect) in Schizophrenia

et al. 1990

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Single-Photon Emission Computerised Tomography (Spect) in Schizophrenia

et al. 1990

View full text Add to dashboard Cite

show abstract

“…Detection of rCBF is seen as secondary marker of neuronal activity. Sensitivity and specificity for the epileptogenic focus is low with interictal SPECT but significantly increased with ictal application and comparison with interictal perfusion patterns [ 11 – 13 ]. Subtraction interictal from ictal SPECT and coregistration to MRI (SISCOM) further increased sensitivity and specificity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

PET and ictal SPECT can be helpful for localizing epileptic foci

Oertzen

2018

Current Opinion in Neurology

View full text Add to dashboard Cite

Purpose of reviewFunctional neuroimaging with PET and SPECT is a commonly used tool in presurgical evaluation. The following article reviews the literature of PET and SPECT in presurgical assessment of epilepsies published in the last year.Recent findingsFDG-PET adds concomitant information in temporal and extratemporal lobe epilepsy in adults and children. The pattern of hypometabolism in FDG-PET is a good additional predictor or seizure outcome in TLE with mesial temporal sclerosis or negative MRI. There is growing evidence that diagnostic value of FDG-PET increases with postprocessing. Although several methods were applied in the reviewed literature, all of them seem to outperform the visual analysis. Imaging of the epileptic focus with ictal SPECT is depending on short injection latencies. It is particularly useful in patients with nonlesional MRI and mostly of extratemporal localization. Areas of hyperperfusion remote of SOZ are reflecting the epileptic network. Combining more concordant investigations including PET and SPECT in MRI-negative evaluation adds to better presurgical stratification and therefore, better postsurgical outcome. FET-PET shows increased uptake in status epilepticus.SummaryPET and SPECT are important investigations to localize the epileptic focus in temporal lobe and nonlesional extratemporal epilepsies. Postprocessing for both modalities is important to increase diagnostic value.

show abstract

“…The distribution pattern of HMPAO within the brain reflects rCBF at the time of the first passage through CNS. Since CBF correlates closely with regional cerebral metabolism, HMPAO SPECT scanning apparently images both 1 . MRI is a neuroimaging method which can show more of the pathological changes in the brain than CT scanning.…”

Section: Single Photon Emission Computed Tomography (Spect) and Magnetic Resonance Imaging (Mri) Have Recently Been Shown To Be Useful Asmentioning

confidence: 99%

MRI and brain spect findings in patients with unilateral temporal lobe epilepsy and normal CT scan

Carrilho

Yacubian

Cukiert

et al. 1994

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

26 patients with temporal lobe epilepsy clinically documented by several abnormal interictal surface EEGs with typical unitemporal epileptiform activity and a normal CT scan were studied. Interictal 99mTC HMPAO brain SPECT and MRI were performed in all subjects. Abnormalities were shown in 61.5% of MRI (n = 16) and 65.4% of SPECT (n = 17). Hippocampal atrophy associated to a high signal on T2-weighted MRI slices suggesting mesial temporal sclerosis was the main finding (n = 12; 75% of abnormal MRI). MRI correlated well to surface EEG in 50% (n = 13). There was also a good correlation between MRI and SPECT in 30.7% (n = 8). SPECT and EEG were in agreement in 57.7% (n = 15). MRI, SPECT and EEG were congruent in 26.9% (n = 7). These results support the usefulness of interictal brain SPECT and MRI in detecting lateralized abnormalities in temporal lobe epilepsy. On the other hand, in two cases, interictal SPECT correlated poorly with surface EEG. This functional method should not be used isolately in the detection of temporal lobe foci. MRI is more useful than CT as a neuroimaging technique in temporal lobe epilepsy. It may detect small structural lesions and mesial temporal lobe sclerosis which are not easily seen with traditional CT scanning.

show abstract

99mTc-LABELLED HEXAMETHYLPROPYLENEAMINE OXIME PHOTON EMISSION SCANS IN EPILEPSY

Cited by 19 publications

References 2 publications

Single-Photon Emission Computerised Tomography (Spect) in Schizophrenia

Single-Photon Emission Computerised Tomography (Spect) in Schizophrenia

PET and ictal SPECT can be helpful for localizing epileptic foci

MRI and brain spect findings in patients with unilateral temporal lobe epilepsy and normal CT scan

Contact Info

Product

Resources

About