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Abstract

ABSTRACT:In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as 'smart drug carriers' for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. In present scenario, the major challenge for the researchers is ocular drug delivery system as eye is the most sensitive organ in our body. Topical eye drop is the best suited way for delivery of drugs for the treatment of anterior segment of the eye. Delivery of the drugs to the targeted areas is restricted by the various barriers and even the amount instilled do not remain there for a long duration of time. In the past many years scientist are working on providing the masses the way for delivering drug in a novel, safe and patience compliance manner. The aided the basic delivery by providing the administration through various permeation enhancers and viscosity modifiers. Widely studied subjects in nanoscience technology is related to the conception of supramolecular architectures with well-defined structures and functionalities. Nanomicelles have congregated considerable attention in the field of drug and ocular drug delivery due to their exceptional biocompatibility, low toxicity, enhanced blood circulation time.

A Review on Newer Ocular Drug Delivery Systems with an Emphasis on Glaucoma

“…112 Nanomicelles are advantageous as they maintain an ideal concentration of the medicament in the respected targets, better patient compliance, easy to prepare, small in size and improves the availability of medications in visual tissues. 113 The utility of micellar scale preparations are limited as it may experience rapid tear dilution, untimely drug release & cost. 114 Elmowafy et al reported the possibility of a better evolved therapy in glaucoma using nanomicelles.…”