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Abstract

The ameliorative effects of Moringa oleifera L. (M. oleifera) is well known to modulate and enhance several immune parameters. The present study investigates the efficacy of the aqueous extract leaves of the M. oleifera on prevention of acetaminophen (APAP) induced acute renal injury in Wistar rats. Thirty albino rats were arranged randomly into 5 groups of 5 rats. Group 2 served as intoxicated group and received APAP (200 mg/kg). Group 3, 4 and 5 received APAP (200 mg/kg) + M. oleifera at doses 250, 500 and 1000 mg/kg, respectively. While first group was served as control rats group. All treatment was given orally to animals for 14 days. Clinical signs were observed regularly and rats were sacrificed and bloods and tissue samples were collected for biochemical and histological analysis. Biochemical results showed that M. oleifera protected the toxic remarks caused by APAP when decrease the elevated levels of serum creatinine, blood urea, cholesterol and lipids, while increases the plasma levels of total protein and albumin. Also, the nephroprotective effects of extracts was strongly correlated with decreased damage of the renal cellular damage, as evidenced by histological findings when compared to the group treated with APAP. Our findings provide evidence to demonstrate that aqueous extract of M. oleifera has a potent nephroprotective effect on APAP-induced kidney injury in rats. It is proposed that the action of plant is through its antioxidative and its ability to restoration or promoting glutathione (GSH) through decrease in the biotransformation of APAP via cytochrome P-450 pathway.