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Yurkshtovich, T. L.; Alinovskaya, V. A.; Butrim, N. S.

doi:10.1023/a:1015937313737

Cited by 7 publications

(4 citation statements)

References 1 publication

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“…4 Moreover, oxidized cellulose is among the largest used hemostatic materials in surgery. 5 The presence of carboxyl groups also allows for immobilizing drugs via ionic 6 or covalent 7 bonding. These properties and its complete bioresorbtion render the oxidized cellulose a medical material with high application potential.…”

Section: Introductionmentioning

confidence: 99%

Mild and Selective Oxidation of Cellulose Fibers in the Presence of N-Hydroxyphthalimide

et al. 2009

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The oxidation reaction of regenerated cellulose fibers mediated by N-hydroxyphthalimide (NHPI) and various cocatalysts at room temperature for different time intervals and various amounts of low concentration sodium hypochlorite solution has been investigated to produce oxidized cellulose (OC), a biocompatible and bioresorbable polymer. The results revealed that the nonpersistent phthalimide-N-oxyl (PINO) radical generated in situ from NHPI in both, metallic or metal-free systems, is a powerful agent in this kind of transformation. Moreover, the reaction converts highly selectively C(6) primary hydroxyl groups to carboxylic groups under mild reaction conditions and shorter reaction times than previously reported. The amounts of negatively charged groups in OC were determined by means of potentiometric titration. Further characterization of the products were accomplished by using Fourier transform infrared spectroscopy/attenuated total internal reflection spectroscopy (FT-IR/ATR), environmental scanning electron microscopy (ESEM), and X-ray and energy-dispersive X-ray (EDX) spectroscopy. Notably, water retention values of the oxidized fibers increased by 30% in comparison with the original nonoxidized sample, as a result of the introduction of hydrophilic carboxylate groups.

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Section: Introductionmentioning

confidence: 99%

Mild and Selective Oxidation of Cellulose Fibers in the Presence of N-Hydroxyphthalimide

et al. 2009

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“…OC has been shown to possess antitumor,7 immunostimulant,8 wound‐healing,9 and adhesion‐prevention properties 10, 11. The presence of carboxyl groups in OC permits the immobilization of drugs via ionic12 or covalent13 bonds, as well as the preparation of polymer drugs with a variety of therapeutic effects. These properties, as well as complete bioabsorption, characterize OC as a medical material with very high potential 14.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of oxidized cellulose

Zimnitsky

Yurkshtovich

Bychkovsky

2004

J. Polym. Sci. A Polym. Chem.

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Samples of oxidized cellulose (OC) with various carboxyl contents and degrees of crystallinity were obtained by the oxidation of native and mercerized cellulose with a solution of nitrogen(IV) oxide in CCl4. A detailed characterization of these OC samples was performed. The effect of oxidation conditions (concentration of N2O4 in the solution and oxidation time) and starting cellulose material on OC characteristics (carboxyl, carbonyl and nitrogen content, degree of crystallinity and polymerization, surface area and swelling, and acidic properties) was investigated. Reactivity in the oxidation process was higher in mercerized cellulose than in native cellulose. The action of dilute solutions (10–15%) of N2O4 did not affect the degree of crystallinity of cellulose samples. Under these conditions, the oxidation took place mainly in amorphous regions and on the surface of crystallites. Oxidation in a concentrated (40%) N2O4 solution led to the destruction of crystallites, which increased the surface area and swelling of cellulose in water. The surface area and the swelling of OC samples increased with a decrease in the index of crystallinity. The acidic properties of OC were shown to increase with an increase of swelling in water. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4785–4791, 2004

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“…OC has been shown to possess antitumor [4], immunostimulant [5], wound-healing [6], and adhesion-prevention properties [7,8]. The presence of carboxyl groups at C6 in OC permits the immobilization of drugs by adsorption [9] and preparation of polymer drugs with a variety of therapeutic effects. These properties, as well as complete bioabsorption [10], characterize OC as a medical material with very high potential.…”

Section: Introductionmentioning

confidence: 99%