A 10-Year, Double-Blind Study

Gogan, William J.; Fraser, Robert D.

doi:10.1097/00007632-199204000-00002

Cited by 80 publications

(43 citation statements)

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“…Fewer than half (17/36, 47%) of chemonucleolysis studies were RCTs, and only one of these 206 was good quality (comparator was inactive control). Eleven studies 47,85,88,160,168,170,205,[207][208][209][210] were of moderate quality. One study 206 used both adequate randomisation and allocation concealment (comparator included inactive control).…”

Section: Summary Of Study Design and Quality For Chemonucleolysis Stumentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Lewis

Williams²,

Matar³

et al. 2011

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTAThe clinical effectiveness and costeffectiveness of management strategies for sciatica: systematic review and economic model NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA pro...

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Section: Summary Of Study Design and Quality For Chemonucleolysis Stumentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Lewis

Williams²,

Matar³

et al. 2011

Health Technol Assess

View full text Add to dashboard Cite

show abstract

“…However, reports followed of a significant complication rate, including mortality [37,38]. The incidence of mortality is extremely small -about 0.02% [14,47]; and a 0.5% incidence of anaphylaxis was reported by Agre et al in 1984 [1]. This could be reduced to 0.02% by prior testing for chymodiactin sensitivity and by excluding patients with a history of sensitivity [25].…”

Section: Chemonucleolysismentioning

confidence: 99%

“…The incidence of infection after discography may be reduced to 0.7% by using an appropriate two-needle technique [13]. Significant muscle spasm, which occurs in the immediate postoperative period and is self-limiting, may occur in up to 40% of cases [14,27]. Strict guidelines to ensure appropriate patient selection and safe techniques were introduced in 1987; since then no major neurological or anaphylactic complications have been reported [21].…”

Section: Chemonucleolysismentioning

confidence: 99%

Minimally invasive disc surgery: a review

Krugluger

Knahr

2001

International Orthopaedics

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“…In 5 double-blind studies, the result with chemonucleolysis was satisfactory in 72 (58-80) percent, with placebo 50 (42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57) percent. In a double-blind study of chymopapain versus placebo injection, with 10-year follow-up, a sustained better therapeutic effect of chymopapain was demonstrated (Gogan and Fraser 1992). A compilation of long-term results in 3130 patients (Nordby 1986) showed satisfactory results in 77 (66-93) percent.…”

mentioning

confidence: 97%

Chymopapain chemonucleolysis

Konings

1993

Acta Orthopaedica Scandinavica

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A 10-Year, Double-Blind Study

Cited by 80 publications

References 0 publications

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Minimally invasive disc surgery: a review

Chymopapain chemonucleolysis

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