A 13‐week vapor inhalation study of 3,3‐dimethyl‐2‐butanol in sprague‐dawley rats

Abstract

Four groups of male and female Sprague-Dawley rats were exposed for 13 weeks to 3,3-dimethyl-2-butanol (PA) at concentrations of 0.00, 0.20, 1.00 or 5.00 mg/l (1 mg/l = 240 ppm). Exposures were for 6 hr per day, 5 days per week with sacrifices at 7 and 13 weeks of exposure, and at 4 weeks after exposure. The test animals were evaluated for abnormalities in physiology, behaviour, clinical laboratory parameters, and gross and microscopic morphology. No abnormalities were detected in electrocardiograms, respiratory indices, spontaneous activity, passive avoidance activity and open-field behaviour. Clinical signs related to PA exposure included alopecia, ataxia and lacrimation. There were no biologically significant between-group differences in body-weights during the study. The clinical laboratory data demonstrated a 30% increase in serum cholesterol and bilirubin at 7 weeks in high-dose males and an increase in urea nitrogen in intermediate and high-dose males at 13 weeks. There were no abnormalities in hematologic or coagulation parameters. At necropsy there were no significant gross abnormalities; however, examination of organ weights revealed enlarged kidneys in high-dose male rats at 13 weeks, enlarged ovaries in high-dose female rats at 13 weeks, and microscopic study of tissue sections revealed minimal to mild renal tubular injury in high and possibly intermediate dose males at several sacrifices. These findings suggest that the primary target organ of PA, when given by inhalation, is the kidney in male rats and possibly the ovary in female rats. The renal changes in the high-dose males were not fully reversible during the recovery period.(ABSTRACT TRUNCATED AT 250 WORDS)

Toxic Alcohols: Aliphatic Saturated Alcohols

“…Inhalation studies with rats have shown ataxia, mild hypoxemia, hypercapnia, and lacrimation (James et al 1987b). LCLo in rat was 4930 mg/kg for a 6 hours exposure period per day for 13 week inhalation study (James et al 1987a). The rats also showed depressed respiration and reduced motor activity upon an exposure.…”

A novel gaseous pinacolyl alcohol sensor utilizing cataluminescence on alumina nanowires prepared by supercritical fluid drying

“…The concentration range of pinacolyl alcohol investigated should be lower than 5 mg L −1 , which was compatible with the requirements of the industry or other stakeholders [19,20]. The aim of this paper is to develop a highly selective pina- colyl alcohol sensor based on CTL for the determination of pinacolyl alcohol in workplace air.…”

Relationships between structure and induction of hyaline droplet accumulation in the renal cortex of male rats by aliphatic and alicyclic hydrocarbons

“…A rapidly growing number of chemicals -principally aliphatic or aromatic hydrocarbons -have been reported to induce a characteristic spectrum of morphological changes in the kidney unique to the male rat (Carpenter et al 1975a(Carpenter et al , b, 1977Parker et al 1981;Alden et al 1984;Phillips and Cockrell 1984;Phillips and Egan 1984;Collins and Manus 1987;James et al 1987;Kanerva et al 1987a;Phillips et al 1987;Bomhard et al 1988Bomhard et al , 1989.…”