A 13-Year Retrospective Study on Primary Liver Cancer in Cambodia: A Strikingly High Hepatitis C Occurrence among Hepatocellular Carcinoma Cases

Chassagne, François; Rojas, Teresa Rojas; Bertani, Stéphane; Bourdy, Geneviève; Eav, Sokha; Ruíz, Eloy; Pineau, Pascal; Deharo, Eric

doi:10.1159/000446398

Cited by 15 publications

(8 citation statements)

References 35 publications

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“…In recent years, worldwide, almost half of the patients with HCC have been diagnosed positive for HCV (Chassagne et al 2016;El-Serag and Mason 1999). This has been confirmed in a study we conducted at the Calmette hospital in Cambodia on around 500 patients, where HCV was associated with half the cases of HCC, with higher prevalence in women (Chassagne et al 2016). In Laos, comprehensive epidemiological data are lacking but those obtained by Jutavijittum et al (2007), aggregated to ours, are a source of concern.…”

Section: Discussionsupporting

confidence: 83%

Hepatitis C in Laos: A 7-Year Retrospective Study on 1765 Patients

et al. 2018

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Hepatitis C virus (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV-induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly diagnosed by rapid test in health centres was conducted at the Centre of Infectiology Lao Christophe Merieux in Vientiane. The demographic information of patients, their infection status (viral load: VL), liver function (aminotransferases) and treatments were analysed. Results showed that gender distribution of infected people was balanced; with median ages of 53.8 for men and 51.6 years for women (13-86 years). The majority of patients (72%) were confirmed positive (VL > 50 IU/mL) and 28% of them had high VL (> 6log). About 23% of patients had level of aminotransferases indicative of liver damage (> 40 IU/mL); but less than 20% of patients received treatment. Patients rarely received a second sampling or medical imaging. The survey also showed that cycloferon, pegylated interferon and ribavirin were the drugs prescribed preferentially by the medical staff, without following any international recommendations schemes. In conclusion, we recommend that a population screening policy and better management of patients should be urgently implemented in the country, respecting official guidelines. However, the cost of biological analysis and treatment are significant barriers that must be removed. Public health resolutions should be immediately enforced in the perspective of meeting the WHO HCV elimination deadline by 2030.

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Section: Discussionsupporting

confidence: 83%

Hepatitis C in Laos: A 7-Year Retrospective Study on 1765 Patients

et al. 2018

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“…33 Moreover, a retrospective study performed in Cambodia identified the serologic marker of HCV infection in 11.5% of CCA cases. 34 Interestingly, HCV infection had also been identified as a risk factor for biliary intraepithelial neoplasia, a precursor lesion of CCA, including mucinous iCCA and mixed iCCA. The analysis of 244 liver explants obtained between 1995 and 2007 at the Mayo Clinic from cases of liver cirrhosis and controls demonstrated the relation between HCV infection and/or alcohol cirrhosis and biliary intraepithelial neoplasia.…”

Section: Epidemiologic Association Of Hcv Infection and Ccamentioning

confidence: 99%

Hepatitis C Virus Infection and Cholangiocarcinoma

Navas

Glaser

Dhruv

et al. 2019

The American Journal of Pathology

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Hepatitis C virus (HCV) infection is a global public health problem because it is a main cause of liver cirrhosis and hepatocellular carcinoma. This human oncogenic virus is also associated with the development of non-Hodgkin lymphoma and cholangiocarcinoma (CCA). The association between HCV infection and CCA has been examined in a number of epidemiologic studies. However, in vivo and in vitro results demonstrating the oncogenic mechanisms of HCV in CCA development and progression are insufficient. Here, we review the epidemiologic association of HCV and CCA and recent publications of studies of HCV infection of cholangiocytes and CCA cell lines as well as studies of viral infection performed with liver samples obtained from patients. In addition, we also discuss the preliminary results of in vitro assays of HCV protein expression in CCA cell lines. Finally, we discuss the hypothetical role of HCV infection in CCA development by induction of epithelialemesenchymal transition and up-regulation of hedgehog signaling, and consequently biliary tree inflammation and liver fibrosis. Further studies are required to demonstrate these hypotheses and therefore to elucidate the mechanisms of HCV as a risk factor for CCA.

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“…3 HCV is a major contributor to liver cancer and overall cancer deaths in Cambodia and Asia. 4,5 Southeast Asia has the second highest burden of viral hepatitis mortality globally. 1 More than 11 million people are estimated to have antibodies to HCV in this region, 6 with 2.3% of Cambodians exposed to HCV.…”

Section: Introductionmentioning

confidence: 99%

“…HCV is a major contributor to liver cancer and overall cancer deaths in Cambodia and Asia 4,5 . Southeast Asia has the second highest burden of viral hepatitis mortality globally 1 .…”

Section: Introductionmentioning

confidence: 99%