A 15-Year Longitudinal Follow-Up Study of Heart Rate and Heart Rate Variability in Healthy Elderly Persons

Tasaki, Hirofumi; Serita, Takumi; Irita, Akiko; Hano, Osamu; Iliev, Ivan; Ueyama, Chiaki; Kitano, Kouei; Seto, Shinji; Hayano, Motonobu; Yano, Katsusuke

doi:10.1093/gerona/55.12.m744

Cited by 29 publications

(24 citation statements)

References 15 publications

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“…10 The significant decrease in 24-h mean mean NN seen in the present study (ie, the significant increase in 24-h mean HR) might be derived from an increase in plasma norepinephrine or sympathetic nervous activities with age, 26 a deterioration in cardiopulmonary function, a decrease in muscarinic receptors, 27 an attenuation of the whole ANA 4 with increasing age, etc.…”

Section: Age-related Changes In Hr and Hrvmentioning

confidence: 54%

“…Previously, we reported changes in HR and HRV with aging over 15 years in healthy elderly patients during the night (00.00 to 05.00) and day (noon to 17.00), 10 when HR and HRV are thought to be relatively stable in circadian rhythm. [20][21][22] However, from a clinical point of view, it is in the morning that cardiovascular events most frequently occur.…”

Section: Discussionmentioning

confidence: 99%

“…However, the increasing tendency in 24-h mean HF as the index of parasympathetic activity over a whole day, which seems to be paradoxical in elderly patients in whom sympathetic activities are thought to increase, 21 might imply a negative feedback phenomenon of parasympathetic nerves to such increased sympathetic activities with age, 28 probably as a result of the decrease in metabolism of norepinephrine with age at the synapses of efferent sympathetic nerves in the sinus node 10,29 or in the circulating blood.…”

Section: Age-related Changes In Hr and Hrvmentioning

confidence: 99%

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Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Tasaki

Serita

Ueyama

et al. 2006

Circ J

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Section: Age-related Changes In Hr and Hrvmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Age-related Changes In Hr and Hrvmentioning

confidence: 99%

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Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Tasaki

Serita

Ueyama

et al. 2006

Circ J

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“…Most participants were generally inactive (86%), with some exceptions, accounting for the outliers in the distribution for activity level. The average heart rate was approximately 70 bpm, in the normal range for elderly persons (21). Table 4 presents the results of several statistical models for estimating the effect of ambient temperature, heart rate, and activity level on body temperature in the summer of 2000 using hourly medians.…”

Section: Resultsmentioning

confidence: 99%

An exposure assessment study of ambient heat exposure in an elderly population in Baltimore, Maryland.

Basu

Samet

2002

Environ Health Perspect

116

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Because of concern for heat-related mortality in vulnerable populations, particularly the elderly, practical epidemiologic methods are needed for the assessment of ambient heat exposure on individuals. We used a personal monitor to measure body temperature, ambient temperature, heart rate, and activity level of 42 elderly residents of Baltimore, Maryland, in the summer months of 2000. Each participant was monitored for approximately 48 hr to examine the association between ambient temperature and body temperature, using regression methods that account for highly correlated data within individuals. We also examined the associations of Baltimore temperature data with personal ambient temperature and body temperature. An average 0.15 degrees F [95% confidence interval (CI), 0.05-0.25] increase in median body temperature was found for each 1 degrees F increase in median ambient temperature. Heart rate and activity level were not found to be related to body temperature or ambient temperature, although heart rate was associated with activity level. Median heart rate increased an average of 0.17 (95% CI, 0.13-0.21) beats per minute for every unit increase in median activity level. Personal ambient temperature was slightly lower than Baltimore temperatures, whereas an association was not found between body temperature and Baltimore temperatures. The protocol established in this study for heat exposure assessment could feasibly be applied on a larger scale.

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“…Differences between age groups in cross‐sectional studies could be related to selective survival among older people rather than genuine effects. A small number of longitudinal studies on age‐related HRV changes have been conducted 11, 17, 18, 19, 20, 21. Of these, only a few are population based,18, 19, 20, 21 and others have relied on small samples of elderly participants 12, 13.…”

Section: Introductionmentioning

confidence: 99%

Are Changes in Heart Rate Variability in Middle‐Aged and Older People Normative or Caused by Pathological Conditions? Findings From a Large Population‐Based Longitudinal Cohort Study

Jandackova

Scholes

Britton

et al. 2016

JAHA

108

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BackgroundNo study to date has investigated longitudinal trajectories of cardiac autonomic modulation changes with aging; therefore, we lack evidence showing whether these changes occur naturally or are secondary to disease or medication use. This study tested whether heart rate variability (HRV) trajectories from middle to older age are largely normative or caused by pathological changes with aging in a large prospective cohort. We further assessed whether HRV changes were modified by socioeconomic status, ethnicity, or habitual physical activity.Methods and ResultsThis study involved 3176 men and 1238 women initially aged 44 to 69 years (1997–1999) from the UK Whitehall II population‐based cohort. We evaluated time‐ and frequency‐domain HRV measures of short‐term recordings at 3 time points over a 10‐year period. Random mixed models with time‐varying covariates were applied. Cross‐sectionally, HRV measures were lower for men than for women, for participants with cardiometabolic conditions, and for participants reporting use of medications other than beta blockers. Longitudinally, HRV measures decreased significantly with aging in both sexes, with faster decline in younger age groups. HRV trajectories were not explained by increased prevalence of cardiometabolic problems and/or medication use. In women, cardiometabolic problems were associated with faster decline in the standard deviation of all intervals between R waves with normal‐to‐normal conduction, in low‐frequency HRV, and in low‐frequency HRV in normalized units. Socioeconomic status, ethnicity, and habitual physical activity did not have significant effects on HRV trajectories.ConclusionsOur investigation showed a general pattern and timing of changes in indices of cardiac autonomic modulation from middle to older age. These changes seem likely to reflect the normal aging process rather than being secondary to cardiometabolic problems and medication use.

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A 15-Year Longitudinal Follow-Up Study of Heart Rate and Heart Rate Variability in Healthy Elderly Persons

Abstract: HR increased with age over the 15-year period in the healthy elderly persons. As for concurrent changes in HRV, however, the parameters of sympathetic modulation decreased, and the parameters of parasympathetic modulation were unchanged or slightly increased.

Cited by 29 publications

References 15 publications

Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

An exposure assessment study of ambient heat exposure in an elderly population in Baltimore, Maryland.

Are Changes in Heart Rate Variability in Middle‐Aged and Older People Normative or Caused by Pathological Conditions? Findings From a Large Population‐Based Longitudinal Cohort Study

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