A 16‐bp deletion in the canine <i><scp>PDK</scp>4</i> gene is not associated with dilated cardiomyopathy in a <scp>E</scp>uropean cohort of <scp>D</scp>oberman <scp>P</scp>inschers

Owczarek‐Lipska, Marta; Mausberg, Theresa-Bernadette; Stephenson, Hannah; Dukes‐McEwan, J.; Wess, Gerhard; Leeb, Tosso

doi:10.1111/j.1365-2052.2012.02396.x

Cited by 31 publications

(20 citation statements)

References 3 publications

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“…mRNA levels were associated with 14-fold reduction in Doberman Pinscher carriers compared with what was observed in normal dogs of other breeds. However, a subsequent European study of Doberman Pinschers with dilated cardiomyopathy did not replicate the findings, reporting essentially the same mutation rate (16%) among cases and controls (Owczarek-Lipska et al 2013b). It remains to be seen how this story plays out.…”

Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 83%

“…Congestive heart failure is observed in many breeds (Isono et al 2012), as are cardiomyopathy (Mausberg et al 2011, Meurs et al 2012, Owczarek-Lipska et al 2013b), ventricular arrhythmia ( Jesty et al 2013), and mitral valve disease (Fox 2012, French et al 2012). For some disorders, such as dilated cardiomyopathy in the Irish Wolfhound, many loci are involved (Philipp et al 2012).…”

Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 99%

“…It remains to be seen how this story plays out. At a minimum it suggests that additional genes remain to be found (Owczarek-Lipska et al 2013b). Indeed, a GWAS by this group reports a major locus for the disease in Dobermans on chromosome 5 (Mausberg et al 2011).…”

Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 99%

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Insights into Morphology and Disease from the Dog Genome Project

Schoenebeck

Ostrander

2014

Annu. Rev. Cell Dev. Biol.

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Although most modern dog breeds are less than 200 years old, the symbiosis between man and dog is ancient. Since prehistoric times, repeated selection events have transformed the wolf into man’s guardians, laborers, athletes, and companions. The rapid transformation from pack predator to loyal companion is a feat that is arguably unique among domesticated animals. How this transformation came to pass remained a biological mystery until recently: Within the past decade, the deployment of genomic approaches to study population structure, detect signatures of selection, and identify genetic variants that underlie canine phenotypes is ushering into focus novel biological mechanisms that make dogs remarkable. Ironically, the very practices responsible for breed formation also spurned morbidity; today, many diseases are correlated with breed identity. In this review, we discuss man’s best friend in the context of a genetic model to understand paradigms of heritable phenotypes, both desirable and disadvantageous.

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Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 83%

Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 99%

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Insights into Morphology and Disease from the Dog Genome Project

Schoenebeck

Ostrander

2014

Annu. Rev. Cell Dev. Biol.

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“…DoCM is characterized by three stages. DP in stage one are presumed to have genetic mutations which lead to myocardial alteration on a subcellular level but the majority of cellular changes that occur is still unknown (26,27). However, affected heart mitochondrial protein expression, increased oxidative stress and evidence for apoptosis have been evidenced (28).…”

Section: Introductionmentioning

confidence: 99%

Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

Schimke

Wess

Wallukat

et al. 2019

Preprint

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“…, Owczarek‐Lipska et al . ) is that some dogs are at increased risk of going on to develop the disease. The second stage of the disease is characterized by electrical instability and mechanical dysfunction of the heart; some dogs demonstrating one of these traits, some both.…”

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confidence: 99%

Thinking outside the box

Boswood¹

2013

J of Small Animal Practice

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Adrian BoswoodMA VetMB DVC DipECVIM-CA(Cardiology) MRCVS Adrian graduated from the University of Cambridge in 1989. In 1990, following a brief period in general practice, he joined the RVC as an intern and has remained there since then. He is now Professor of Cardiology and a European Specialist in Companion Animal Cardiology. His clinical and research interests include the diagnosis and medical management of cardiac disease and failure. He has a particular interest in biomarkers and the diagnosis and management of degenerative mitral valve disease in dogs.

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A 16‐bp deletion in the canine PDK4 gene is not associated with dilated cardiomyopathy in a European cohort of Doberman Pinschers

Cited by 31 publications

References 3 publications

Insights into Morphology and Disease from the Dog Genome Project

Insights into Morphology and Disease from the Dog Genome Project

Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

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