A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat

Emerson, Dawn M.; Davis, J. Mark; Chen, Stephen Cl.; Torres-McGehee, Toni M.; Pfeifer, Craig; Emerson, Charles C.; Bivona, Joseph D.; Stone, Justin V.

doi:10.1016/j.smhs.2020.02.003

Cited by 4 publications

(11 citation statements)

References 34 publications

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“…Seven studies showed no significant Tc difference between non-selective NSAIDs and controls. 36 , 37 , 38 , 39 , 40 , 41 , 42 Across these seven studies, drug dosage varied from low to high doses administered between 1 and 14 days; exercise mode included running, walking, or cycling and ranged from 45 to 90 min; and environment ranged from thermoneutral (18 °C) to hot (38.9 °C).…”

Section: Resultsmentioning

confidence: 99%

“… 18 de Meersman 40 Downey & Darling 67 Emerson et al. 42 Farquhar & Kenney 38 Farquhar et al. 39 Eligibility criteria specified (no points) Subjects were allocated randomly to groups (in a crossover study, subjects were allocated randomly in the order in which treatments were received).…”

Section: Resultsmentioning

confidence: 99%

“… 61 A lack of Tc difference in Emerson et al. 42 may be because peak concentration occurred at the end of exercise. Oral, uncoated aspirin’s affects are rapid, with peak plasma concentration occurring ∼30 min after administration.…”

Section: Discussionmentioning

confidence: 96%

“…The majority of investigations used hot to extremely hot environments (>30 °C dry, wet, or WBGT). 18 , 36 , 37 , 38 , 39 , 42 However, only two studies reported >50% humidity. 42 , 43 The environmental strain among many of the investigations was likely not enough to lead to an uncompensable condition.…”

Section: Discussionmentioning

confidence: 99%

“…60 While the dosage administered by Emerson et al. (220 mg) 42 should have provided an anti-inflammatory effect, higher doses (550 mg) may be necessary. 60 , 61 …”

Section: Discussionmentioning

confidence: 99%

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Non-steroidal anti-inflammatory drugs on core body temperature during exercise: A systematic review

Emerson

Chen

Kelly

et al. 2021

Journal of Exercise Science & Fitness

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Background Because of their anti-pyretic effects, some individuals prophylactically use non-steroidal anti-inflammatory drugs (NSAIDs) to blunt core temperature (Tc) increases during exercise, thus, potentially improving performance by preventing hyperthermia and/or exertional heat illness. However, NSAIDs induce gastrointestinal damage, alter renal function, and decrease cardiovascular function, which could compromise thermoregulation and increase Tc. The aim of this systematic review was to evaluate the effects of NSAIDs on Tc in exercising, adult humans. Methods We conducted searches in MEDLINE, PubMed, Cochrane Reviews, and Google Scholar for literature published up to November 2020. We conducted a quality assessment review using the Physiotherapy Evidence Database scale. Nine articles achieved a score ≥ seven to be included in the review. Results Seven studies found aspirin, ibuprofen, and naproxen had no effect (p > .05) on Tc during walking, running, or cycling for ≤ 90 min in moderate to hot environments. Two studies found significant Tc changes. In one investigation, 81 mg of aspirin for 7–10 days prior to exercise significantly increased Tc during cycling (p < .001); final Tc at the end of exercise = 38.3 ± 0.1 °C vs. control = 38.1 ± 0.1 °C. In contrast, participants administered 50 mg rofecoxib for 6 days experienced significantly lower Tc during 45 min of cycling compared to placebo (NSAID Tc range ≈ 36.7–37.2 °C vs control ≈ 37.3–37.8 °C, p < 0.05). Conclusions There are limited quality studies examining NSAID effects on Tc during exercise in humans. The majority suggest taking non-selective NSAIDs (e.g., aspirin) 1–14 days before exercise does not significantly affect Tc during exercise. However, it remains unclear whether Tc increases, decreases, or does not change during exercise with other NSAID drug types (e.g., naproxen), higher dosages, chronic use, greater exercise intensity, and/or greater environmental temperatures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

“…60 While the dosage administered by Emerson et al. (220 mg) 42 should have provided an anti-inflammatory effect, higher doses (550 mg) may be necessary. 60 , 61 …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Non-steroidal anti-inflammatory drugs on core body temperature during exercise: A systematic review

Emerson

Chen

Kelly

et al. 2021

Journal of Exercise Science & Fitness

Self Cite

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An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment

Emerson

Chen

Torres-McGehee

et al. 2021

Sports Medicine and Health Science

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A review on the important phytochemicals and their role in psoriasis

Pandey

Shukla

Dubey

et al. 2021

JANS

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Psoriasis may emerge at any stage of life irrespective of age, sex or geographic location. It is identified as a chronic immune-linked inflammatory skin disease that affects all human races. Psoriasis is often more Caucasian than non-Caucasian groups of human races and in geographic areas, like higher latitudes and Western countries. Therefore, attention should be paid to both genetic and environmental causes of psoriasis. Natural products have significantly contributed and encouraged the advances in skin disease treatment like psoriasis. The maximum number of phytochemicals is now being used worldwide, including various plants, herbs, and formulations. In addition, some phytochemicals like psoralen, aloe-emodin, curcumin etc. have also been isolated in pure form and have also shown their efficacy in the management of psoriasis. The presence of such phytochemicals confirms the effectiveness of few herbal therapies. This paper reviews some of the promising phytochemicals and their potential molecular target sites and mechanism of action, which may aid in designing and producing more precise and selective antipsoriatic agents. Exploring and recognizing phytochemicals as to how they function will facilitate more site-specific delivery methods for psoriasis care.

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A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat

Cited by 4 publications

References 34 publications

Non-steroidal anti-inflammatory drugs on core body temperature during exercise: A systematic review

Non-steroidal anti-inflammatory drugs on core body temperature during exercise: A systematic review

An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment

A review on the important phytochemicals and their role in psoriasis

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