A 25-mm diameter probe for photoacoustic and ultrasonic endoscopy

Yang, Joon-Mo; Chen, Ruimin; Favazza, Christopher P.; Yao, Junjie; Li, Chiye; Hu, Zhongliang; Zhou, Qifa; Shung, K. Kirk; Wang, Lihong V.

doi:10.1364/oe.20.023944

Cited by 113 publications

(125 citation statements)

References 48 publications

(53 reference statements)

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“…Real in vivo photoacoustic endoscopy imaging was accomplished only recently. 227 Despite these challenges, a few designs of combined OCT/photoacoustic endoscopes have been tested, as are shown in Figs. 15 and 16.…”

Section: Implementations Of Dual-modality Oct/photoacoustic Imaging Smentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

432

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Implementations Of Dual-modality Oct/photoacoustic Imaging Smentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

432

264

View full text Add to dashboard Cite

show abstract

“…Our main interest is to adapt the PAI system for the endoscopic scanning in the cervical canal. The endoscopic photoacoustics has always been a main branch in the field of photoacoustic research, which has already been demonstrated in the imaging of vascular and esophagus [33,34]. Small endoscopic photoacoustic catheter with a diameter of 2.5 mm has been reported [34].…”

Section: Discussionmentioning

confidence: 99%

“…The endoscopic photoacoustics has always been a main branch in the field of photoacoustic research, which has already been demonstrated in the imaging of vascular and esophagus [33,34]. Small endoscopic photoacoustic catheter with a diameter of 2.5 mm has been reported [34]. Because the majority of the patients with CC are women who have had babies, their cervical canals can be expanded easily.…”

Section: Discussionmentioning

confidence: 99%

Detection of cervical cancer based on photoacoustic imaging—the in-vitro results

Peng

Wang

et al. 2014

Biomed. Opt. Express

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Abstract:In current clinical practice, the diagnosis of cervical cancer (CC) is mainly through the cervical screening followed by a necessary biopsy, but this method is labor consuming and expensive, and can only detect superficial lesions around the external cervical orifice. In contrast, photoacoustic imaging (PAI) is sensitive to the abnormal angiogenesis deep in the biological tissue, and may be capable for the intact scanning both around the external orifice and in cervical canal. In this paper, we for the first time put forward the photoacoustic diagnosis of CC. A total of 30 invitro experiments were carried out in this study, and the obtained depth maximum amplitude projection (DMAP) images were analyzed to evaluate the extent of the angiogenesis for different clinical stages of CC. Stronger absorption from the cervical lesions is observed relative to that of normal tissue. Paired t-test indicates that the difference in mean optical absorption (MOA) between normal tissue and cervical lesion has statistical significance with a confidential coefficient of 0.05. Statistical results also show that the MOAs of the cervical lesions are closely related to the severity of CC. These results imply that PAI may have great utility in the clinical diagnosis of CC. Phys. 39(11), 6895-6899 (2012).

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“…Fully encapsulated AR-PAM endoscopes have been demonstrated by Yang et al [17,18] using a single mode fiber and an actuation system for the beam steering. Recently OR-PAM images have been acquired by the same group using a device with an outer diameter of 3.4 mm and a lateral resolution of 9.2 μm [19].…”

Section: Introductionmentioning

confidence: 99%

Towards new applications using capillary waveguides

Stasio¹,

Shibukawa²,

Papadopoulos³

et al. 2015

Biomed. Opt. Express

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Abstract:In this paper we demonstrate the enhancement of the sensing capabilities of glass capillaries. We exploit their properties as optical and acoustic waveguides to transform them potentially into high resolution minimally invasive endoscopic devices. We show two possible applications of silica capillary waveguides demonstrating fluorescence and opticalresolution photoacoustic imaging using a single 330 μm-thick silica capillary. A nanosecond pulsed laser is focused and scanned in front of a capillary by digital phase conjugation through the silica annular ring of the capillary, used as an optical waveguide. We demonstrate optical-resolution photoacoustic images of a 30 μm-thick nylon thread using the water-filled core of the same capillary as an acoustic waveguide, resulting in a fully passive endoscopic device. Moreover, fluorescence images of 1.5 μm beads are obtained collecting the fluorescence signal through the optical waveguide. This kind of silica-capillary waveguide together with wavefront shaping techniques such as digital phase conjugation, paves the way to minimally invasive multi-modal endoscopy.

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A 25-mm diameter probe for photoacoustic and ultrasonic endoscopy

Cited by 113 publications

References 48 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Detection of cervical cancer based on photoacoustic imaging—the in-vitro results

Towards new applications using capillary waveguides

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