A 28- Day Oral Toxicity Study of Pseudocedrela kotschyi Methanol Extract in Sprague-Dawley Rats

Abubakar, Kabiru; Muhammad, Danjuma; Bello, Mustapha Mohammed; Akpojo, Anuka Joseph; YamMun, Fei; Oricha, Bello Shaibu; Yusoff, Nor Adlin; HorSook, Yee; Ahmad, Mariam; Asmawi, Zaini

doi:10.9734/ejmp/2015/20199

Cited by 7 publications

(4 citation statements)

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“…The 28-day acute oral toxicity study of P. kotschyi demonstrated a lack of methanol extract toxicity. Behavioral, biochemical, hematological and weight data showed no toxicity [71].…”

Section: Toxicity Studymentioning

confidence: 86%

A Literature Review—Khaya senegalensis, Anacardium ouest L., Cassia sieberiana DC., Pterocarpus erinaceus, Diospyros mespiliformis, Ocimum gratissimum, Manihot esculenta, Vernonia amygdalina Delile, Pseudocedrela kotschyi and &

Dougnon¹,

Hounsa²,

Koudokpon³

et al. 2020

ABB

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The rise in antimicrobial resistance increases researchers' interest in medicinal plants used for traditional treatment of infectious diseases. The study is based on ten (10) medicinal plants mostly cited in the treatment of diarrhea in West Africa: Khaya senegalensis, Anacardium ouest L., Cassia sieberiana DC., Pterocarpus erinaceus, Diospyros mespiliformis, Ocimum gratissimum, Manihot esculenta, Vernonia amygdalina Delile, Pseudocedrela kotschyi, Daniellia oliveri. The objective is to make a review on ethnopharmacological, pharmacological, toxicological and chemical data that enhance these medicinal plants in the fight against diarrheal infections. Specific keywords were used for bibliographic research in Google Scholar, Science Direct, PubMed Directory of Open Access Journals (DOAJ) and other databases. Generalities relating to diarrheal infections and scientific data on the ten selected plants in the fight against diarrheal infections were sought. From the results, it emerges that each of the ten plants has been listed as useful in the traditional treatment of diarrheal infections.

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“…The 28-day acute oral toxicity study of P. kotschyi demonstrated a lack of methanol extract toxicity. Behavioral, biochemical, hematological and weight data showed no toxicity [71].…”

Section: Toxicity Studymentioning

confidence: 86%

A Literature Review—Khaya senegalensis, Anacardium ouest L., Cassia sieberiana DC., Pterocarpus erinaceus, Diospyros mespiliformis, Ocimum gratissimum, Manihot esculenta, Vernonia amygdalina Delile, Pseudocedrela kotschyi and &

Dougnon¹,

Hounsa²,

Koudokpon³

et al. 2020

ABB

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“…All the doses used were no toxic for the animal and literature data are shown that Ceiba pentandra is not toxic at the doses of 2 g/kg [19] and for Pseudocedrela kotschyi DL50 by oral route is 1750 g/kg [20].…”

Section: Evaluation Of Antipyretic Activitymentioning

confidence: 90%

“…Otherwise, the results of previous toxicity study have revealed that these plants might be considered as a broad non-toxic one. Indeed, traditional used and toxicological studies have revealed the safety and security of these two plants (Comestible and natural remedies) [7,20,23].…”

Section: Discussionmentioning

confidence: 99%

The Onset of Action of Aqueous Extracts of Ceiba pentandra (Malvaceae) and Pseudocedrela kotschyi (Meliaceae) Plants with Potential Antipyretic Activity on Young Rats and their Interactions with Antimalaria Drugs (Artemisinin-based Combination)

Atl¹,

KE²,

Any-Grah-Aka³

et al. 2018

J Clin Exp Pharmacol

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Background: Several classical antipyretics are used to treat fever. But their harmful sides effects have led to the research of the others alternative based on medicine herbals. Rarely, studies are focused on the onset of action and assess the effects of Drugs Herbal interaction in vivo using experimental models. The main objective of this work is to assess potential antipyretic activities of two African plants (Ceiba pentandra and Pseudocedrela kotschyi concerning the onset of action and evaluate the effects of their association to the combination based on artemisinin (CTA). Methods: Turpentine 2 ml/kg, yeast brewers 20%, boiled milk 1 ml/kg were used to induce fever in young rats. The crudes of the extract of Ceiba pentandra 200 mg/kg; 400 mg/kg and Pseudocedrela kotschyi 100 and 150 mg/kg were administered orally and the temperatures (°C) were taken each 10 minutes. The Drugs-Herbal medicine interactions were also assessed (Extracts of our plants plus CTA). GraphPad Prism software version 7 was used to analyse the data. The difference was considered significant when P<0.05. Results: Aqueous extract of the Ceiba pentandra and Pseudocedrela kotschyi quickly reduce the fever by reducing the onset time of action (10-30 minutes). P-value<0.001 but our study has shown pharmacodynamics interaction between CTA and Pseudocedrela. There may have some interaction between CTA and the natural compounds contained in these medicine plants that reduce their efficacy. Conclusion: This present study showed the onset action of our two plants is between 10-30 minutes. Their association with CTA reduce the efficacy of extracts aqueous of leaves of Pseudocedrela kotschyi 150 mg/kg but no Ceiba pendantra 400 mg. They may be used as an alternative to classical drugs as antipyretics especially in children. But others studies may be done to assess the pharmacokinetic pharmacodynamics interactions with association based on artemisinin.

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“…The animals were controlled and monitored in a clean metal cage containing sawdust as bedding material with routine cleaning and disinfection throughout the period of study. They were allowed to acclimatize to the laboratory andfed between 123.9 g -187 g body weight (Kabiru et al, 2015;Gaiuson et al, 2020).…”

Section: Laboratory Animalmentioning

confidence: 99%

Effects of Trypanosoma brucei on thyroid hormones in albino rats

Yaduma,

Wahedi,

Buba

et al. 2024

AFRJBS

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Infections with trypanosomes bring about various modifications in the body. Thyroid hormone affects almost all body organs. Thyroids are secreted by the thyroid gland in three forms namely; triiodothyronine (T3), tetraiodothyronine (T4) and thyroid stimulating hormone (TSH). The aim of this research is to investigate the effects of Trypanosoma brucei on thyroid hormone and the functioning of liver and kidney in albino rats. The effect of T. brucei on these hormones was investigated by setting up two groups A and B (treatment and control) each comprising of ten albino rats. The control group were not infected by T. brucei while the treated group were infected. The concentrations of the thyroid hormones in serum were measured using Enzyme-Linked Immunosorbent Assay (ELISA) at seven-day interval for a period of twentyeight days. Data were analyzed using the graph pad prism. There were no significant changes (p>0.05) observed in the level of TSH in week 1 of the treated group (3.09 ± 0.14) compared to the control (2.77 ± 0.19). At week 2 there was also no-significant decrease (p>0.05) in TSH level (3.04 ± 0.20) compared to control (3.35 ± 0.13). At week 3, there is significant decrease in the treated group when compared to the control (2.74 ± 0.11 vs. 3.40 ± 0.13). In the first week of treatment T3 level was non-significant when compared to the control group (0.20 ± 0.02 vs. 0.23 ± 0.02); T3 level was significantly lower (p< 0.05) in the second week compared to the control (0.12 ± 0.01 vs. 0.23 ± 0.03). At week three T3 level was significantly lower (p<0.05) compared to the control group (0.15 ±0.01 vs. 0.19 ± 001). There was a non-significant decrease (p>0.05) in the level of T4 in the treated group when compared to the control group at week 1 (5.42 ± 0.23 vs. 5.60 ± 0.21). At week 2 T4 level was non-significantly lower (p>0.05) in treated group compared to group B (5.31 ± 0.25 vs. 5.87± 0.15). At week 3 group A significantly reduced (p<0.05) in the treated group compared to the control (4.81 ± 0.24 vs. 5.65 ± 0.10). In conclusion, Trypanosoma brucei infection depresses thyroid gland functions which causes reduced production of the thyroid hormones which in turn causes hepatic and renal toxicities in albino rats.

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A 28- Day Oral Toxicity Study of Pseudocedrela kotschyi Methanol Extract in Sprague-Dawley Rats

Cited by 7 publications

References 0 publications

A Literature Review—<i>Khaya senegalensis, Anacardium ouest</i> L., <i>Cassia sieberiana</i> DC., <i>Pterocarpus erinaceus</i>, <i>Diospyros mespiliformis</i>, <i>Ocimum gratissimum</i>, <i>Manihot esculenta</i>, <i>Vernonia amygdalina</i> Delile, <i>Pseudocedrela kotschyi</i> and &

A Literature Review—<i>Khaya senegalensis, Anacardium ouest</i> L., <i>Cassia sieberiana</i> DC., <i>Pterocarpus erinaceus</i>, <i>Diospyros mespiliformis</i>, <i>Ocimum gratissimum</i>, <i>Manihot esculenta</i>, <i>Vernonia amygdalina</i> Delile, <i>Pseudocedrela kotschyi</i> and &

The Onset of Action of Aqueous Extracts of Ceiba pentandra (Malvaceae) and Pseudocedrela kotschyi (Meliaceae) Plants with Potential Antipyretic Activity on Young Rats and their Interactions with Antimalaria Drugs (Artemisinin-based Combination)

Effects of Trypanosoma brucei on thyroid hormones in albino rats

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