A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation

Ren, Yuan; Chen, Qiang; Li, Zhiyong

doi:10.1186/1475-925x-14-s1-s11

Cited by 26 publications

(29 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing intramural pressure on the connective parts of the ACoA complex can initiate the process of remodeling the blood vessel resulting in the formation of an aneurysmal sac and then to its rupture [17]. In an experimental study with rabbits Ersin et al demonstrated the hemodynamic effect of increased perfusion requirements in the formation of aneurysms [24], and Guangyu Zhu and al.…”

Section: Discussionmentioning

confidence: 99%

Influence of Circle of Willis Configuration on the Rupture of Cerebral Aneurysms

Nebojša¹,

Aleksandar²,

Mitić³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Formation and rupture of cerebral aneurysms may be related to certain types of configuration of the circle of Willis. Analysis of their interdependence can be of great importance. Methods: A group of 114 patients treated operatively for the cerebral aneurysm rupture and a group of 56 autopsied subjects were involved in the study. Four basic types of the circle of Willis configurations were formed–two symmetric types A and C, and two asymmetric types B and D. Results: A statistically significantly higher presence of asymmetry of the circle of Willis in the group of surgically treated subjects (p=0.006) with a significant presence of asymmetric Type B in this group (p=0.017) were determined. The presence of changes in the A1 segment in the group of subjects with solitary aneurysms on the anterior communicating artery showed a statistically significant presence in the group of autopsied subjects (p=0.0004). Analyzing the presence of symmetry of the circle of Willis between the two groups, that is, the total presence of symmetric types A and C indicated their statistically significant presence in the group of autopsied patients (p=0.043). Conclusion: Changes such as hypoplasia or aplasia of A1 and the resulting asymmetry of the circle of Willis directly affect the possibility of the rupture of cerebral aneurysms. Detection of the corresponding types of the circle of Willis after diagnostic examination can be the basis for the development of a protocol for monitoring such patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Circle of Willis Configuration on the Rupture of Cerebral Aneurysms

Nebojša¹,

Aleksandar²,

Mitić³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…An idealized model could be a simple one based on limited geometric parameters [47], a local 3D geometry coupled with 0D artery tree at inlet and outlets [48], or a structure rebuilt from the in-vitro model [49,50]. More patient-specifically, some idealized models were reconstructed from the central lines extracted from the clinical imaging of intracranial arteries [51][52][53] or an intact arterial structure starting from the aorta [5], or derived from changing the topology of CoW reconstructed from patientspecific CT images [54]. In-vivo geometric models were reconstructed exactly from the patient-specific imaging data.…”

Section: ) Methods To Improve Accuracymentioning

confidence: 99%

State-of-the-Art Computational Models of Circle of Willis With Physiological Applications: A Review

et al. 2020

View full text Add to dashboard Cite

Background: Various computational models of the circle of Willis (CoW) have been developed to non-invasively estimate the blood flow and hemodynamic parameters in intracranial arteries for the assessment of clinical risks such as aneurysms, ischemia, and atherosclerotic plaque growth. This review aims to categorize the latest computational models of CoW and summarize the innovative techniques. Summary of Review: In traditional computational models of CoW, the computational complexity increased from zero-dimensional models to one-dimensional and three-dimensional models. The applications extend from estimating certain hemodynamic parameters to simulating local flow field. The innovative techniques include the combination of models with different dimensions, the extension of vascular structure including heart and veins, as well the addition of distal fractality, cerebral autoregulation, and intracranial pressure. There are some nontraditional models based on fluid-solid-interaction, control theory, and in-vitro experiments. In all kinds of models, the in-vivo data and non-Newtonian rheological models of blood have been widely applied to improve the accuracy of hemodynamic simulation. Conclusion: Firstly, the selection of model depends on its application scenario. The balance between computational complexity and physiological accuracy deserves further investigation. Secondly, the improvement of CoW models relies on the large-scale validations and the combination of various innovative modeling techniques. INDEX TERMS brain modeling, computational modeling, Circle of Willis (CoW), Windkessel effect, pulse wave, computational fluid dynamics (CFD), cerebral blood flow, intracranial arteries.

show abstract

“…Another physiological variable that is critical to determining outcome is the degree of collateral circulation possessed by stroke victims. [ 17 ] The more perfusion pathways possessed by a given area of the brain, the greater the degree and duration of ischemia necessary to produce damage.…”

Section: Ischemic Stroke and Transient Ischemic Attackmentioning

confidence: 99%

The cerebral circulation and cerebrovascular disease III: Stroke

Chandra

Stone

et al. 2017

Brain Circ

View full text Add to dashboard Cite

A 3D numerical study of the collateral capacity of the circle of Willis with anatomical variation in the posterior circulation

Abstract: Background: The Circle of Willis (CoW) is the most important collateral pathway of the cerebral artery. The present study aims to investigate the collateral capacity of CoW with anatomical variation when unilateral internalcarotid artery (ICA) is occluded.

Cited by 26 publications

References 33 publications

Influence of Circle of Willis Configuration on the Rupture of Cerebral Aneurysms

Influence of Circle of Willis Configuration on the Rupture of Cerebral Aneurysms

State-of-the-Art Computational Models of Circle of Willis With Physiological Applications: A Review

The cerebral circulation and cerebrovascular disease III: Stroke

Contact Info

Product

Resources

About