A 40‐week phase 2B randomized, multicenter, double‐blind, placebo‐controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis
Salman Bhai,
Todd Levine,
Dan Moore
et al.
Abstract:IntroductionAmyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no known cure, limited treatment options with minimal benefits, and significant unmet need for disease modifying therapies.AimsThis study investigated memantine's impact on ALS progression, with an additional focus on the effects of memantine on cognitive and behavioral changes associated with the disease.MethodsA randomized, double‐blind, placebo‐controlled clinical trial was conducted from December 2018 to… Show more
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