A 430nW 64nV/vHz current-reuse telescopic amplifier for neural recording applications

Song, Shunfeng; Rooijakkers, Michiel; Harpe, Pieter; Rabotti, C.; Mischi, Massimo; Roermund, Arthur van; Cantatore, Eugenio

doi:10.1109/biocas.2013.6679704

Cited by 30 publications

(18 citation statements)

References 11 publications

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“…This inadequacy becomes more pronounced, as recent works have reported operating supply voltages below 1 V [49, 129, 156]. Recently, Muller et al [86] introduced the power efficiency factor (PEF), which takes into account both the operating current and the supply voltage and therefore provides a better comparison of the amplifier’s performance.…”

Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

“…This leads to a reduction in the thermal noise component of the input-referred noise (and hence the NEF) by a factor of √2. Amplifiers using this topology achieve state-of-the-art noise performance [49, 129, 156]. Although this current-reuse technique is a promising method for reducing the thermal noise component, it doubles the gate capacitance of the input differential pair.…”

Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

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Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Greenwald

et al. 2016

Med Biol Eng Comput

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Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification.

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Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

Section: Background On Neural Recording Amplifiersmentioning

confidence: 99%

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Greenwald

et al. 2016

Med Biol Eng Comput

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“…The detailed circuit of the proposed IA is shown in Fig.2, in which the core amplifier (Gm1) uses two PMOS and NMOS input pairs sharing the same current but achieves double transconductance as a single input pair, namely current-reuse technology [8]. In order to work at low supply voltage and achieve high transconductance-efficiency for input transistors, M1~M12 works in sub-threshold region.…”

Section: A the Principle Of Current-reuse Amplifiermentioning

confidence: 99%

“…Because the chopping operation switches the mismatch of IA within two equal-width phases, the IA will become more symmetric. Consequently, the chopper-stabilized amplifiers share relatively higher CMRR and PSRR than the capacitive couple structure like [7][8]. Fig.1 shows the architecture of the proposed IA, including three loops to achieve good performances such as low noise, high input impedance and high CMRR.…”

Section: Introductionmentioning

confidence: 99%

A 1.3μW 0.7μV<inf>RMS</inf> chopper current-reuse instrumentation amplifier for EEG applications

Huang

Yin

et al. 2015

2015 IEEE International Symposium on Circuits and Systems (ISCAS)

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This paper presents a low noise chopper-stabilized instrumentation amplifier (IA) for EEG recording. The current-reuse technology is adopted to reduce noise of the IA and the regulated cascode circuit is used to boost the open-loop gain of the amplifier. A ripple reduction loop (RRL) based on a novel output-resistance-tuning technology is proposed to reduce the intrinsic offset of the IA and reduce the output ripple of the chopper amplifier. Simulation results show the high-pass cutoff frequency of 0.15Hz, the input referred noise of 0.7μV RMS (BW=100Hz) and a NEF of 2.83. The attenuation to the chopping ripple is about 35dB with the novel output-resistance-tuning based RRL. The proposed IA achieves an average CMRR of 110dB, average PSRR of 105dB and average input-impedance of 1.5GΩ from Monte Carlo analysis. The overall IA consumes only 1.1μA current at a 1.2V supply.

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“…Numerous designs of neural amplifier based on the circuit in Figure 6 or with some variations (e.g., in the realization of the pseudoresistors, use of fully-differential topology with one or two stage OTAs, use of current-reuse techniques to double the transconductance, and so forth [35][36][37][38][39]) have been reported in the literature, including commercial amplifier chips by Intan Technologies, LLC (http://www.intantech.com/). Methods for effective optimization of a recording channel in terms of its power consumption, input-referred voltage noise, silicon area, and technology used are discussed in [40].…”

Section: Continuous-time Techniquesmentioning

confidence: 99%

Advances in Microelectronics for Implantable Medical Devices

Demosthenous

2014

Advances in Electronics

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Implantable medical devices provide therapy to treat numerous health conditions as well as monitoring and diagnosis. Over the years, the development of these devices has seen remarkable progress thanks to tremendous advances in microelectronics, electrode technology, packaging and signal processing techniques. Many of today's implantable devices use wireless technology to supply power and provide communication. There are many challenges when creating an implantable device. Issues such as reliable and fast bidirectional data communication, efficient power delivery to the implantable circuits, low noise and low power for the recording part of the system, and delivery of safe stimulation to avoid tissue and electrode damage are some of the challenges faced by the microelectronics circuit designer. This paper provides a review of advances in microelectronics over the last decade or so for implantable medical devices and systems. The focus is on neural recording and stimulation circuits suitable for fabrication in modern silicon process technologies and biotelemetry methods for power and data transfer, with particular emphasis on methods employing radio frequency inductive coupling. The paper concludes by highlighting some of the issues that will drive future research in the field.

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A 430nW 64nV/vHz current-reuse telescopic amplifier for neural recording applications

Cited by 30 publications

References 11 publications

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

A 1.3μW 0.7μV<inf>RMS</inf> chopper current-reuse instrumentation amplifier for EEG applications

Advances in Microelectronics for Implantable Medical Devices

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A 430nW 64nV/vHz current-reuse telescopic amplifier for neural recording applications

Cited by 30 publications

References 11 publications

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

Implantable neurotechnologies: a review of integrated circuit neural amplifiers

A 1.3&#x03BC;W 0.7&#x03BC;V<inf>RMS</inf> chopper current-reuse instrumentation amplifier for EEG applications

Advances in Microelectronics for Implantable Medical Devices

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A 1.3μW 0.7μV<inf>RMS</inf> chopper current-reuse instrumentation amplifier for EEG applications